Objective: To evaluate the vascular response at 9 months after zotarolimus-eluting stent (ZES) implantation using optical coherence tomography (OCT). These findings were compared with those after sirolimus-eluting stent (SES).
Design: Cross-sectional observational study with prospective OCT registry.
Setting: Nine months after ZES or SES implantation.
Design and patients: A total of 68 patients (32 ZES and 36 SES) underwent OCT procedure at 9 months after stent implantation. NIH (neointima hyperplasia) thickness inside each strut and percentage of NIH area at every 1 mm cross-section were measured.
Main outcome measurement: The degree of neointimal coverage and the prevalence of malapposition at 9 months after ZES and SES implantation using OCT.
Results: The mean NIH thickness (251.2±110.0 μm vs. 85.5±53.3 μm, p<0.001) and percent of NIH area (27.9±9.2 % vs. 11.2±7.1 %, p< 0.001) were significantly greater in ZES as compared to SES. The prevalence of exposed strut as well as malapposed strut were significantly lower in ZES (0.3 % vs. 12.2 %, p<0.001 and 0.01 % vs. 2.6 %, p<0.001). Thrombus was not observed in ZES (0.0 % in ZES vs. 27.8 % in SES, P = 0.001).
Conclusions: Neointimal coverage in ZES was almost complete and malapposition was very rare at 9-month follow up.
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