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Optical Coherence Tomography Evaluation of Zotarolimus-eluting Stents at 9 Month Follow Up: Comparison with Sirolimus-eluting stents
  1. Jung-Sun Kim (kjs1218{at}yuhs.ac)
  1. Yonsei University, Korea, Republic of
    1. Ik-Kyung Jang
    1. Massachusetts general hospital, Harvard Medical schol, United States
      1. Jin-Sun Kim
      1. Yonsei University, Korea, Republic of
        1. Tae Hoon Kim
        1. Yonsei University, Korea, Republic of
          1. Masamichi Takano
          1. Nippon Medical School, Japan
            1. Teruyoshi Kume
            1. Kawasaki Medical School, Japan
              1. Nam Wook Hur
              1. Yonsei University, Korea, Republic of
                1. Young-Guk Ko
                1. Yonsei University, Korea, Republic of
                  1. Donghoon Choi
                  1. Yonsei University, Korea, Republic of
                    1. Myeong-Ki Hong
                    1. Yonsei University, Korea, Republic of
                      1. Yangsoo Jang (jangys1212{at}yuhs.ac)
                      1. Yonsei University, Korea, Republic of

                        Abstract

                        Objective: To evaluate the vascular response at 9 months after zotarolimus-eluting stent (ZES) implantation using optical coherence tomography (OCT). These findings were compared with those after sirolimus-eluting stent (SES).

                        Design: Cross-sectional observational study with prospective OCT registry.

                        Setting: Nine months after ZES or SES implantation.

                        Design and patients: A total of 68 patients (32 ZES and 36 SES) underwent OCT procedure at 9 months after stent implantation. NIH (neointima hyperplasia) thickness inside each strut and percentage of NIH area at every 1 mm cross-section were measured.

                        Main outcome measurement: The degree of neointimal coverage and the prevalence of malapposition at 9 months after ZES and SES implantation using OCT.

                        Results: The mean NIH thickness (251.2±110.0 μm vs. 85.5±53.3 μm, p<0.001) and percent of NIH area (27.9±9.2 % vs. 11.2±7.1 %, p< 0.001) were significantly greater in ZES as compared to SES. The prevalence of exposed strut as well as malapposed strut were significantly lower in ZES (0.3 % vs. 12.2 %, p<0.001 and 0.01 % vs. 2.6 %, p<0.001). Thrombus was not observed in ZES (0.0 % in ZES vs. 27.8 % in SES, P = 0.001).

                        Conclusions: Neointimal coverage in ZES was almost complete and malapposition was very rare at 9-month follow up.

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