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Functional Outcomes After the Ross (Pulmonary Autograft) Procedure assessed with Magnetic Resonance Imaging and Cardiopulmonary exercise testing
  1. Rajesh Puranik (rajpuranik{at}hotmail.com)
  1. Royal Prince Alfred Hospital, Sydney, Australia
    1. Victor Tsang (tsangvt{at}aol.com)
    1. Great Ormond Street Hospital, London, United Kingdom
      1. Andrew Broadley (a.j.m.broadley{at}lineone.net)
      1. Great Ormond Street Hospital for Children, United Kingdom
        1. Johannes Nordmeyer (nordmj{at}gosh.nhs.uk)
        1. UCL Institute of Child Health and Great Ormond Street Hospital for Children, United Kingdom
          1. Phillip Lurz (lurzp{at}gosh.nhs.uk)
          1. UCL Institute of Child Health and Great Ormond Street Hospital for Children, United Kingdom
            1. Nagarajan Muthialu (nagarm{at}gosh.nhs.uk)
            1. Great Ormond Street Hospital for Children, United Kingdom
              1. Derrick Graham (derrig{at}gosh.nhs.uk)
              1. Great Ormond Street Hospital for Children, United Kingdom
                1. Fiona Walker (fiona.walker{at}uclh.nhs.uk)
                1. The Heart Hospital, United Kingdom
                  1. Seamus Cullen (shay.cullen{at}uclh.nhs.uk)
                  1. The Heart Hospital, United Kingdom
                    1. Marc de Leval (marc.deleval{at}hcahealthcare.co.uk)
                    1. Great Ormond Street Hospital for Children, United Kingdom
                      1. Phillip Bonhoeffer (bonhop{at}gosh.nhs.uk)
                      1. Great Ormond Street Hospital for Children, United Kingdom
                        1. Andrew Taylor (a.taylor{at}ich.ucl.ac.uk)
                        1. UCL Institute of Child Health and Great Ormond Street Hospital for Children, United Kingdom
                          1. Vivek Muthurangu (v.muthurangu{at}ich.ucl.ac.uk)
                          1. UCL Institute of Child Health and Great Ormond Street Hospital for Children, United Kingdom

                            Abstract

                            Objective: To assess autograft, homograft and ventricular function, as well as exercise capacity, in adult patients who have undergone the Ross procedure.

                            Setting: Single centre paediatric and adult congenital heart disease unit.

                            Patients: 45 subjects (24.6y, range 16.9-52.2y) who underwent the Ross procedure between 1994 and 2006 (8.1y post Ross operation, range 2.0-14.0y).

                            Interventions: Cardiovascular magnetic resonance imaging, echocardiography and cardiopulmonary exercise testing.

                            Main outcome measures: Autograft and homograft stenosis, and regurgitation. Autograft size. Bi-ventricular function, scar volume and exercise capacity.

                            Results: Mean autograft regurgitation was 6.8±8.3% (trivial regurgitation) and diameter was 40.0±7.0mm. Mean homograft velocity was 2.4±0.6m/s (mild-moderate stenosis) and regurgitation was 6.1±8.3% (trivial regurgitation). Biventricular systolic function was normal (LV EF 63.1± 6.4% and RV EF 60.1± 7.6%). In 38% of cases there was evidence of LV scar, mostly noted within the inter-ventricular septum. The mean exercise capacity achieved was 87± 22% of predicted. There was no correlation between exercise capacity and ventricular function or scar.

                            Conclusion: This study demonstrates minor autograft and homograft dysfunction in the majority of patients post Ross procedure, associated with good ventricular function and exercise capacity. In addition, minor scar was present in a third of patients with no functional consequences.

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