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Obesity and cardiovascular thrombotic events in patients undergoing percutaneous coronary intervention with drug-eluting stents
  1. Zhi Jian Wang (nongfu1975{at}126.com)
  1. Department of Cardiology, Anzhen Hospital, Capital Medical University, China
    1. Yu Jie Zhou (yjzhou{at}hotmail.com)
    1. Department of Cardiology, Anzhen Hospital, Capital Medical University, China
      1. Yu Yang Liu
      1. Department of Cardiology, Anzhen Hospital, Capital Medical University, China
        1. Miao Yu
        1. Department of Cardiology, Anzhen Hospital, Capital Medical University, China
          1. Dong Mei Shi
          1. Department of Cardiology, Anzhen Hospital, Capital Medical University, China
            1. Ying Xin Zhao
            1. Department of Cardiology, Anzhen Hospital, Capital Medical University, China
              1. Yong He Guo
              1. Department of Cardiology, Anzhen Hospital, Capital Medical University, China
                1. Wan Jun Cheng
                1. Department of Cardiology, Anzhen Hospital, Capital Medical University, China
                  1. Bin Nie
                  1. Department of Cardiology, Anzhen Hospital, Capital Medical University, China
                    1. Hai Long Ge
                    1. Department of Cardiology, Anzhen Hospital, Capital Medical University, China
                      1. De An Jia
                      1. Department of Cardiology, Anzhen Hospital, Capital Medical University, China
                        1. Shi Wei Yang
                        1. Department of Cardiology, Anzhen Hospital, Capital Medical University, China
                          1. Zhen Xian Yan
                          1. Department of Cardiology, Anzhen Hospital, Capital Medical University, China

                            Abstract

                            Background: Previous studies have reported conflicting findings regarding the relationship of body mass index (BMI) to outcomes following percutaneous coronary interventions (PCI). No study to date has directly examined the effect of obesity on cardiovascular thrombotic events after stent implantation.

                            Objective: To evaluate the effect of obesity on cardiovascular thrombotic events in patients undergoing PCI with drug-eluting stents.

                            Methods: we studied 4,972 patients between January 2004 and December 2006. Patients were divided into three groups according to body mass index: normal (BMI < 24.9 kg/m2, n = 1,284); overweight (BMI 25- 29.9 kg/m2, n = 2,475) and obese (BMI > 30 kg/m2, n = 1,213). Median follow-up was 26 (interquartile range 20¨C33) months.

                            Results: Composite cardiovascular thrombotic events, including cardiac death and non-fatal myocardial infarction, were significantly higher in obese patients (5.9%) than in normal (3.2%) and overweight (3.8%) patients (p = 0.001). The incidence of definite or probable stent thrombosis steadily increased with increasing body mass index (0.9% vs 1.0% vs 1.9% in normal, overweight, and obese patients, respectively; p = 0.029). Multivariate analyses showed that obesity was an independent predictor of 3-year composite thrombotic events (hazard ratio = 1.86; 95% confidence interval = 1.25-2.75; p = 0.003) and definite or probable stent thrombosis (hazard ratio = 2.17; 95% confidence interval = 1.04-4.55; p = 0.040).

                            Conclusions: Obese patients have a higher risk for long-term cardiovascular thrombotic events following PCI with drug-eluting stents than patients with normal weight.

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