Background: Adiponectin is an adipose-derived plasma protein that exhibits beneficial actions on the heart. Recently, it was shown that adiponectin levels were elevated in systolic heart failure patients.
Objective: We investigated the association between adiponectin levels and left ventricular (LV) diastolic function in patients with hypertrophic cardiomyopathy (HCM), characterized by diastolic dysfunction.
Methods: Twenty-six patients with HCM showing LV ejection fraction of >60 % were enrolled. We measured LV pressure half-time (T1/2) as an index of myocardial relaxation. Patients were divided into 2 groups on the basis of baseline T1/2 (group A: T1/2< 35 ms, group B: T1/2≥ 35 ms). Blood samples were simultaneously collected from the coronary sinus (CS) and aortic root (Ao) as well as the peripheral vein (PV) for measurement of plasma adiponectin levels.
Results: Plasma adiponectin levels were significantly higher in group B than in group A. Adiponectin levels in PV were positively correlated with the baseline T1/2 in patients with HCM. The transcardiac gradient of adiponectin as calculated by the Ao-CS difference was significantly higher in group A than in group B. The transcardiac gradient of adiponectin also inversely correlated with the baseline T1/2 and adiponectin levels in PV in HCM patients. The expression of AdipR1 but not AdipoR2 in the heart decreased in group B. The baseline T1/2 was negatively associated with AdipoR1 expression in patients with HCM. Conclusions: These data document that adiponectin is an indicator of LV diastolic dysfunction in patients with HCM.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.