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Adiponectin acts as a positive indicator of left ventricular diastolic dysfunction in patients with hypertrophic cardiomyopathy.
  1. Kazumasa Unno
  1. Nagoya University, Japan
    1. Rei Shibata (rshibata{at}med.nagoya-u.ac.jp)
    1. Nagoya University, Japan
      1. Hideo Izawa
      1. Nagoya University, Japan
        1. Akihiro Hirashiki
        1. Nagoya University, Japan
          1. Yosuke Murase
          1. Nagoya University, Japan
            1. Takashi Yamada
            1. Nagoya University, Japan
              1. Masakazu Kobayashi
              1. Nagoya University, Japan
                1. Akiko Noda
                1. Nagoya University, Japan
                  1. Kohzo Nagata
                  1. Nagoya University, Japan
                    1. Noriyuki Ouchi
                    1. Boston University, Japan
                      1. Toyoaki Murohara
                      1. Nagoya University, Japan
                        1. Toyoaki Murohara
                        1. Nagoya University, Japan

                          Abstract

                          Background: Adiponectin is an adipose-derived plasma protein that exhibits beneficial actions on the heart. Recently, it was shown that adiponectin levels were elevated in systolic heart failure patients.

                          Objective: We investigated the association between adiponectin levels and left ventricular (LV) diastolic function in patients with hypertrophic cardiomyopathy (HCM), characterized by diastolic dysfunction.

                          Methods: Twenty-six patients with HCM showing LV ejection fraction of >60 % were enrolled. We measured LV pressure half-time (T1/2) as an index of myocardial relaxation. Patients were divided into 2 groups on the basis of baseline T1/2 (group A: T1/2< 35 ms, group B: T1/2≥ 35 ms). Blood samples were simultaneously collected from the coronary sinus (CS) and aortic root (Ao) as well as the peripheral vein (PV) for measurement of plasma adiponectin levels.

                          Results: Plasma adiponectin levels were significantly higher in group B than in group A. Adiponectin levels in PV were positively correlated with the baseline T1/2 in patients with HCM. The transcardiac gradient of adiponectin as calculated by the Ao-CS difference was significantly higher in group A than in group B. The transcardiac gradient of adiponectin also inversely correlated with the baseline T1/2 and adiponectin levels in PV in HCM patients. The expression of AdipR1 but not AdipoR2 in the heart decreased in group B. The baseline T1/2 was negatively associated with AdipoR1 expression in patients with HCM. Conclusions: These data document that adiponectin is an indicator of LV diastolic dysfunction in patients with HCM.

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