Article Text

other Versions

PDF
Epicardium-derived cells: a new source of regenerative capacity
  1. Joaquim M Vieira,
  2. Paul R Riley
  1. Molecular Medicine Unit, University College London Institute of Child Health, London, UK
  1. Correspondence to Paul R. Riley, Molecular Medicine Unit, University College London Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, United Kingdom; p.riley{at}ich.ucl.ac.uk

Abstract

Cardiovascular regenerative medicine aims to counter muscle loss post ischaemic disease with the identification of new cellular sources for cardiomyocyte replacement. A number of embryonic and adult cell models have been explored preclinically and in patient trials, but modest outcome, coupled with issues with impaired graft survival and limited/immature (trans-) differentiation alongside host rejection, has left the door open for more therapeutically efficacious sources of myocardial regeneration. Due to its fundamental role in heart development, the epicardium emerges as an obvious candidate. Here, recent findings are reviewed that show adult epicardium-derived cells as a new source of regenerative capacity for heart repair.

Statistics from Altmetric.com

Footnotes

  • Funding British Heart Foundation.

  • Competing interests None.

  • Provenance and peer review Commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.