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The Authors' reply: With thank Dr Forge for these comments1, but suspect that the findings and the purpose of our study have been over-interpreted.2 The relevance of clinical registries has been called into question. As the impact of both measured and unmeasured biases cannot be fully controlled, registries are imprecise tools for estimating the effect size of any treatment. This analysis does not seek to take precedence over randomised clinical trials. Rather, such analyses have utility in supporting existing randomised trial evidence and add to the ‘totality of data’ that informs …
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