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Serum parathyroid hormone and risk of adverse outcomes in patients with stable coronary heart disease
  1. Norma Christine Grandi1,
  2. Lutz Philipp Breitling1,
  3. Harry Hahmann2,
  4. Bernd Wüsten3,
  5. Winfried März4,
  6. Dietrich Rothenbacher1,
  7. Hermann Brenner1
  1. 1Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
  2. 2Schwabenland-Klinik, Isny-Neutrauchburg, Germany
  3. 3Klinik am Südpark, Bad Nauheim, Germany
  4. 4Synlab Center of Laboratory Diagnostics Heidelberg, Eppelheim, Germany
  1. Correspondence to Professor Dr Hermann Brenner, Division of Clinical Epidemiology and Ageing Research C070, German Cancer Research Center, POB 10 19 49, D-69009 Heidelberg, Germany; h.brenner{at}dkfz.de

Abstract

Background and Objective Recent longitudinal studies have suggested an association of high serum parathyroid hormone levels (PTH) with elevated cardiovascular risk in the general population. This study presents analyses of the prognostic value of baseline PTH for subsequent cardiovascular events and all-cause mortality in a high-risk population with stable coronary heart disease.

Methods Based on measurements of PTH levels in 1133 patients recruited at two German rehabilitation clinics and followed over 8 years, multivariate Cox regression analysis was performed to estimate the risk of secondary cardiovascular events (including myocardial infarction, stroke and death due to cardiovascular diseases) and all-cause-mortality according to PTH quartiles (Q1–Q4) and continuous PTH concentrations.

Results During follow-up, 153 cardiovascular events and 124 deaths occurred. Age and sex-adjusted Cox regression analysis yielded statistically significant positive associations of PTH with both cardiovascular event incidence and all-cause mortality (HR (95% CI) per SD increase of PTH: 1.35 (1.21–1.51) and 1.25 (1.11–1.42), respectively). Associations remained essentially unchanged after additional adjustment for multiple cardiovascular risk factors. More detailed dose–response analyses showed strong risk elevation for above-normal levels of PTH (>95th percentile), with essentially no association at lower levels.

Conclusion The results of this first detailed study in a cohort of patients with stable coronary heart disease suggest an independent predictive value of above-normal PTH for the prognosis in patients with stable coronary heart disease.

  • Atherosclerosis
  • cardiovascular diseases
  • cohort studies
  • coronary artery disease (CAD)
  • endocrinology
  • epidemiology
  • mortality
  • parathyroid hormone
  • risk stratification

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Footnotes

  • Funding This study was funded by the Willy Robert Pitzer Foundation (Zanderstrasse 28, 61231 Bad Nauheim, Germany), Association of German Pension Fund Agencies (Ruhrstrasse 2, 10709 Berlin, Germany), German Ministry of Education and Research (Hannoversche Strasse 28–30, 10115 Berlin, Germany).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the Ethic Boards of the medical faculties of the universities of Ulm and Heidelberg and of the Physicians' Chamber of the federal states of Baden-Württemberg and Hessen.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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