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Genetic determinants of coronary heart disease: new discoveries and insights from genome-wide association studies
  1. Riyaz S Patel1,2,3,
  2. Shu Ye1
  1. 1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  2. 2Emory University School of Medicine, Atlanta, Georgia, USA
  3. 3Cardiff University, Cardiff, Wales, UK
  1. Correspondence to Dr Riyaz S Patel & Professor Shu Ye, William Harvey Research Institute, Barts and the London School of Medicine, London WC1E 6BQ, UK; riyaz{at}doctors.org.uk, s.ye{at}qmul.ac.uk

Abstract

With the advent of the Human Genome Project and the genomic era, new tools and methodologies have revitalised genetic research into coronary heart disease (CHD). Unprecedented collaborative efforts are discovering novel risk variants for CHD, with most in hitherto unknown molecular pathways. These findings have stimulated a plethora of follow-up of functional and risk prediction studies to mine this wealth of new data. This review will explore the current state of knowledge of the genetic basis of CHD, with an emphasis on recent genomic studies and how these may eventually lead to the promised goals of new therapeutics and personalised medicine.

  • Coronary artery disease
  • coronary heart disease
  • genetics
  • genomics
  • GWAS

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Footnotes

  • Funding Work in SY's laboratory is supported by the British Heart Foundation and forms part of the research themes contributing to the translational research portfolio of Barts and the London Cardiovascular Biomedical Research Unit, which is supported and funded by the National Institute of Health Research.

  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.

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