Objective To investigate the effects of atorvastatin on endothelial function and low-grade systemic inflammation in subjects with successful surgery for aortic coarctation repair (SCR).
Design Open-label study.
Setting Outpatients visiting the adult congenital heart disease department of our hospital.
Patients 34 young people with SCR.
Interventions Patients with SCR received atorvastatin 10 mg/day (n=17) or no treatment (n=17) for 4 weeks. At baseline and at 4 weeks, endothelial function was assessed by flow-mediated dilatation (FMD) of the right brachial artery, and blood samples were obtained. Serum levels of interleukin (IL) 1b, IL-6 and soluble vascular cell adhesion molecule-1 (sVCAM-1) were determined by ELISA.
Main outcome measures Effects of treatment on FMD and serum levels of IL-1b, IL-6 and sVCAM-1.
Results FMD in the atorvastatin group was significantly improved after 4 weeks (from 6.46±0.95% to 11.24±1.38%, p<0.01), while remaining unchanged in the control group (from 6.74±0.58% to 6.95±0.53%, p=NS). Even though atorvastatin had no effect on serum IL-6 levels (0.62 (0.37–0.88) pg/ml to 0.53 (0.28–0.73) pg/ml, p=NS), it significantly reduced circulating levels of IL-1b (from 1.17 (0.92–1.77) pg/ml to 1.02 (0.75–1.55) pg/ml, p<0.05) and sVCAM-1 (from 883.4 (660.3–1093.1) ng/ml to 801.4 (566.7–1030.2) ng/ml, p<0.05). No changes were seen in serum levels of IL-6, IL-1b and sVCAM-1 in the control group after 4 weeks compared with baseline (p=NS for all).
Conclusions Atorvastatin treatment for 4 weeks in subjects with SCR significantly improved endothelial function and suppressed systemic inflammatory status by decreasing circulating levels of IL-1b and sVCAM-1.
Statistics from Altmetric.com
- nitric oxide
- oxidative stress
- coronary physiology
- congenital heart disease
- platelet activation
- coronary artery disease
- valvular disease
- renal disease
- stable angina
- endothelial function
- interventional cardiology
- acute ischaemic syndromes
SB and DT contributed equally to this work.
Competing interests None.
Patient consent Obtained.
Ethics approval This study was conducted with the approval of the institutional ethics committee of Hippokration Hospital.
Provenance and peer review Not commissioned; externally peer reviewed.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.