Article Text

other Versions

High platelet reactivity to multiple agonists during aspirin and clopidogrel treatment is indicative of a global hyperreactive platelet phenotype
  1. Young-Hoon Jeong1,2,
  2. Yongwhi Park2,
  3. Kevin P Bliden1,
  4. Udaya S Tantry1,
  5. Paul A Gurbel1
  1. 1Sinai Center for Thrombosis Research, Baltimore, Maryland, USA
  2. 2Division of Cardiology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea
  1. Correspondence to Professor Paul A Gurbel, Cardiac Catheterization Laboratory, Sinai Center for Thrombosis Research, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA; pgurbel{at}

Statistics from

To the Editor The study performed by Breet et al1 supported our previous suggestion that a cut-off of >550 aspirin reaction units (ARU) was too high to identify high on-treatment platelet reactivity (HPR).2 The cut-off defined by the highest quartile (461 ARU) from our study2 is remarkably similar to the 454 ARU cut-off value associated with 1-year outcomes in the Breet et al study.1 Moreover, across ARU quartiles, reactivity to ADP and collagen …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • PostScript
    Nicoline J Breet Jochem W van Werkum Heleen J Bouman Johannes C Kelder Ankie M Harmsze Christian M Hackeng Jurriën M ten Berg