Raised troponin in COPD: clinical implications and possible mechanisms
- 1Department of Respiratory Medicine, The London Chest Hospital, Barts Health NHS Trust, London, UK
- 2Centre for Advanced Cardiovascular Imaging, William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts, The London Chest Hospital, London, UK
- Correspondence to Professor Neil C Barnes, Department of Respiratory Medicine, The London Chest Hospital, Barts Health NHS Trust, London E29JX, UK;
Chronic obstructive pulmonary disease (COPD) is predicted to become the sixth leading cause of disability and the third most common cause of death by 2020. Reduced forced expiratory volume in 1s, a hallmark of COPD, is ranked second to smoking and above blood pressure and cholesterol as a predictor of all-cause and cardiovascular mortality. Even in mild to moderate COPD patients succumb to cardiovascular disease rather than respiratory failure although the causative mechanism is unknown.1
Over the past decade it has become apparent that during an exacerbation of COPD, classically defined by the combination of worsening dyspnoea with increased sputum volume and/or purulence, there is subclinical myocardial damage typified by an increase in troponin level and other biomarkers which predict mortality.2–4 The key question relates to the mechanisms behind this rise, since without an understanding of the mechanisms the ability to identify an appropriate intervention that will improve outcome is hindered.
Søyseth and colleagues5 seek to further the understanding of this relationship. Specifically they addressed the important issue as to whether the raised levels of troponin found at exacerbation are chronically raised or are a phenomenon related to the exacerbation itself, and found that the troponin levels were significantly higher in the exacerbator group compared with stable patients. The study compared those patients admitted to hospital for an exacerbation with those from a pulmonary rehabilitation clinic. It is however questionable whether these groups really represent similar populations in …