High-sensitivity cardiac troponin T levels are increased in stable COPD
- Anke M C Neukamm1,2,
- Arne Didrik Høiseth2,3,
- Tor-Arne Hagve2,4,
- Vidar Søyseth2,3,
- Torbjørn Omland1,2
- 1Department of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway
- 2Center for Heart Failure Research and KG Jebsen Cardiac Research Centre, University of Oslo, Oslo, Norway
- 3Department of Pulmonology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway
- 4Unit of Medical Biochemistry, Division of Diagnostics and Technology, Akershus University Hospital, Lørenskog, Norway
- Correspondence to Professor Torbjørn Omland, Division of Medicine, Akershus University Hospital, Sykehusveien 27, Lørenskog 1478, Norway;
- Received 26 November 2012
- Revised 26 November 2012
- Accepted 27 November 2012
- Published Online First 12 January 2013
Objective To assess the distribution of high-sensitivity cardiac troponin T (hs-cTnT) concentrations in stable chronic obstructive pulmonary disease (COPD), and whether hs-cTnT is associated with pulmonary function.
Design Prospectively designed, cross-sectional study.
Setting Outpatient clinic of Norwegian teaching hospital and community-based setting.
Participants Sample of 101 stable COPD patients from the hospital's outpatient clinic and 120 individuals derived from a random general population sample.
Main outcomes Ratio of hs-cTnT in stable COPD patients compared with references from the general population. Change in ratio of hs-cTnT per unit increase of relevant covariables.
Results The crude geometric means of circulating hs-cTnT in the cases and the references were 7.75 and 3.01 ng/l, respectively (p <0.001); that is, a relative ratio of 2.57 (95% CI 2.05 to 3.23). After adjustment for relevant confounders, this ratio was moderately attenuated to 1.65 (1.31–2.08). In the total study cohort, as well as among stable COPD patients, we found a significant positive association between hs-cTnT and interleukin-6 concentrations (p <0.001) and the presence of pathologic Q waves (p=0.023). Among stable COPD patients, one quartile increase in forced expiratory volume 1 was associated with a 39% decrease in hs-cTnT and patient category (Global Initiative of Obstructive Lung Disease classification 2011) was positively associated with hs-cTnT (p trend <0.001) after multivariate adjustment.
Conclusions Stable COPD is independently associated with higher hs-cTnT compared with randomly drawn subjects from the general population. In patients with stable COPD, higher hs-cTnT seems to be associated with immune activation and the severity of the disease.
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