Footnotes

• Contributors I would like to undertake that the above mentioned manuscript has not been published elsewhere, accepted for publication elsewhere or under editorial review for publication elsewhere. There is no relationship with industry or any financial associations that might pose a conflict of interest in connection with the submitted article.

• TR and WS contributed equally to the manuscript.

• Competing interests None.

• Patient consent Obtained.

• Provenance and peer review Not commissioned; internally peer reviewed.