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Impaired endothelial function in persons with obstructive sleep apnoea: impact of obesity—the response
  1. Jonny Hisdal1,
  2. Stefan Agewall2,3,
  3. Torbjørn Omland3,4
  1. 1Section of Vascular Investigations, Oslo Vascular Centre, Oslo University Hospital Aker, Oslo, Norway
  2. 2Department of Cardiology, Oslo University Hospital Ullevål, Oslo, Norway
  3. 3Institute of Clinical Medicine, University of Oslo, Oslo, Norway
  4. 4Division of Medicine, Akershus University Hospital, Lørenskog, Norway
  1. Correspondence to Professor Torbjorn Omland, Division of Medicine, Akershus University Hospital, Sykehusveien, NO-1478 Lørenskog, Norway; torbjorn.omland{at}

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We appreciate Dr Atkinson's letter1 discussing our recent paper on endothelial function and impact of obesity in persons with obstructive sleep apnoea.2 In our study, flow-mediated dilatation (FMD) in the brachial artery was used to measure endothelial function. The FMD method was introduced in 1992 by Celermajer and coworkers and has subsequently been used to investigate endothelial function in numerous studies. Several other non-invasive techniques have also been employed to test endothelial function, but the FMD method has been the most widely used over the years. Since the introduction of the FMD method …

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