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Parathyroid hormone is associated with the LV mass after aortic valve replacement
  1. Marie-Hélène Laflamme1,
  2. Haifa Mahjoub2,
  3. Ablajan Mahmut1,
  4. Marie-Chloé Boulanger1,
  5. Eric Larose2,
  6. Philippe Pibarot2,
  7. Patrick Mathieu1
  1. 1Laboratoire d’Études Moléculaires des Valvulopathies (LEMV), Department of Surgery, Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Laval University, Quebec, Canada
  2. 2Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada
  1. Correspondence to Dr Patrick Mathieu, Institut Universitaire de Cardiologie et de Pneumologie de Québec/Quebec Heart and Lung Institute, 2725 Chemin Ste-Foy Québec, Quebecs, Canada G1V 4G5; patrick.mathieu{at}chg.ulaval.ca

Abstract

Aims LV hypertrophy (LVH) is frequent after aortic valve replacement (AVR) and is often associated with comorbidities, including hypertension, obesity, renal failure and prosthesis-patient mismatch (PPM). However, whether other biological mechanism(s) may participate to LVH after AVR is still unknown. Parathyroid hormone (PTH) may play a role in LVH. However, it is presently unknown whether PTH is associated with LVH in patients that have undergone an AVR.

Methods In this cross-sectional study, 195 patients have been investigated at a mean of 8±3.5 years following AVR. LV function and mass were evaluated by Doppler echocardiography. The plasma levels of PTH, 25-hydroxyvitamin D (25-OHD), calcium and phosphate were measured.

Results There were 102 (52%) patients with LVH after AVR. In univariate analyses, PTH blood level was associated with LV mass (LVMi) and LVH. After adjustment for other risk factors, elevated PTH remained associated with LVMi (p=0.003) and LVH (p=0.02). In turn, the blood levels of 25-OHD and the renal function (GFR) were independently and inversely related to the blood level of PTH.

Conclusions After AVR, the level of PTH is independently associated with LVH. In turn, the level of PTH is related with the renal function and the level of 25-OHD.

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