Footnotes

• Contributors KR drafted the initial manuscript; SSC made critical revisions; both authors made subsequent revisions and approved the final document.

• Funding Funded in part, by US National Heart, Lung, and Blood Institute grants R01 HL105170 and R01 HL122492 to SSC. SSC is the Pauline and Harold Price Chair in Cardiac Electrophysiology at the Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA

• Competing interests None.

• Provenance and peer review Commissioned; internally peer reviewed.