eLetters

760 e-Letters

  • Microcirculation impairment in acute coronary syndrome: It is not always the same story
    Matteo Tebaldi

    We read with great interest the elegant work of Kasula et al. recently published on Heart [1]. The Authors showed that fractional flow reserve (FFR) may be an effective tool to discriminate the long-term functional outcome after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) [1]. This retrospective study included exclusively ACS patients for whom FFR evaluation resulted "flow lim...

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  • Re Larsson et al, Chocolate consumption adn risk fo myocardial infarction: a propspective stusy and meta-analysis
    Barbara J Boucher

    Comment to the Heart Journal website

    re Larsson et al, Chocolate consumption and risk of myocardial infarction: a prospective study and meta-analysis. The findings of Larsson et al are fascinating and in line with earlier reports of cardio-protective effects of chocolate consumption, especially of dark chocolate. Having noticed this in the literature, a colleague and I were inspired to measure the vitamin D con...

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  • Re:It is important to distinguish between HFrEF and HFpEF when interpreting these data
    Brian J Lipworth

    We would like to thank Dr Cunnington for his interest in our study and raising some potentially interesting points . We do not have a breakdown of patients with heart failure ( HF) who had either preserved (HFpEF) or reduced ejection fraction (HFrEF) . Since beta-blockers only have a licensed indication for HFrEF on the basis of an echocardiogram , we do not believe that this is likely to be a relevant factor withi...

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  • Impact of Beta-blocker on The Outcome of Takotsubo Cardiomyopathy
    Ibrahim El-Battrawy

    The article by Isogai et al. published in Heart (1) discuss the use of beta-blockers in patients diagnosed and admitted with takotsubo cardiomyopathy (TTC).

    Although no effective guidelines have been prescribed for the treatment of TTC, it is suggested that a parable could be drawn by comparing the use of beta-blocker and angiotensin-converting-enzyme inhibitors in these patients with that of control subjects a...

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  • It is important to distinguish between HFrEF and HFpEF when interpreting these data
    Colin Cunnington

    In this interesting article, Lipworth and colleagues report that beta -blockers are underused in patients with heart failure (HF) and COPD, compared to those with HF alone. However, they do not quote the proportion of "HF" patients within their dataset who had HF with reduced ejection fraction (HFrEF; left ventricular ejection fraction (LVEF) <40%) and HF with preserved ejection fraction (HFpEF; LVEF >50%). This d...

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  • Hypertrophic cardiomyopathy and the potential influence of etomidate on postoperative outcomes.
    Leigh D White

    We read with interest the paper by Dhillon and colleagues which provided a high quality propensity matched observational study of perioperative outcomes in patients with hypertrophic cardiomyopathy (HCM).1 This study showed no difference in what they defined as 'hard outcomes' such as myocardial infarction, stroke and death. They did however show an increased incidence of composite end points (10%; p= 0.03) such as post-...

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  • Does loneliness and social isolation really increase the risk of CHD and stroke? Pooled results based on quality effect model
    Chang Xu

    Dear editor,

    Loneliness and social isolation may lead to CHD and stroke? Valtorta et al. answered this question in a recent meta-analysis [1]. After pooling evidence based on 16 cohorts, they found that poor social relationships increase the risk of CHD and stroke. However, do things really like this? Maybe not. The problem is the random-effect (RE) model they used, which may lead to overconfident and biased re...

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  • Midregional pro-atrial natriuretic peptide and N-terminal pro-B natriuretic peptide for pediatric heart failure diagnosis
    zhi-de hu
    Midregional pro-atrial natriuretic peptide and N-terminal pro-B natriuretic peptide for pediatric heart failure diagnosis Running title Natriuretic peptides for pediatric HF diagnosis Guo-Ming Zhang,1 Zhi-De Hu2 1 Department of Laboratory Medicine, Shuyang People's Hospital, Shuyang, China 2 Department of Laboratory Medicine, The General Hospital, Jinan Military Command Region of PLA, Jinan, Shandong, China Correspondence to...
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  • Fontan conversion is a dated approach to the Failing Fontan
    Louise Coats

    We read with great interest the report by van Melle et al. who conducted a retrospective multi-centre European study to assess surgical options for the failing Fontan [1]. Firstly, we would like to acknowledge the effort made to bring together the results of these infrequently performed, difficult interventions. However, we would also like to highlight concerns with the conclusions reached from this historical mixed regi...

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  • Loneliness and social isolation and increased risk of of coronary heart disease and stroke: clinical implications
    Redford B. Williams

    The recent meta-analysis published in Heart by Valtorta et al. (1) showed that loneliness and social isolation are associated with increased coronary heart disease and stroke incidence in 16 large longitudinal studies conducted in high income countries. This finding is not surprising given the extensive literature documenting such harmful consequences of social isolation, including a study my research group published i...

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