756 e-Letters

  • Causes of sleep deprivation in cardiac patients in hospital settings
    Tanu Pramanik
    Tanu Pramanik Senior Lecturer (Psychology) Effect of sleep deprivation on cardiac patients is an well documented clinical entity which the authors of the current article established with experimental data and therefore deserve sincere applause(1). WHO guideline: The World Health Organization guidelines say that for a good sleep, sound level should not exceed 30 dB(A) for continuous background noise, and 45 dB(A) for individual no...
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  • Response to the letter regarding the article "Early beta-blocker use and in-hospital mortality in patients with Takotsubo cardiomyopathy"
    Toshiaki Isogai

    We would like to thank Professor Madias for his comments and interest in our study.[1] We appreciate the editors of Heart for giving us the opportunity to reply. The Diagnosis Procedure Combination database in Japan contains hospital administrative claims data and discharge abstracts representing approximately 50% of all inpatient admissions to acute-care hospitals in Japan.[2] As per the request by Professor Madias, we...

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  • Takotsubo syndrome in a Japanese patient cohort: an opportunity to tap into a great resource!
    John E. Madias

    To the Editor: The report by Isogai al,1 published online ahead of print on February 15, 2016 in the Journal, about the 2672 patients (81.5% women) who had suffered Takotsubo syndrome (TTS) between 2010 and 2014, deriving from the "Diagnosis Procedure Combination nationwide inpatient database in Japan" is an invaluable resource, since it comprises all patients with this pathology admitted to acute-care hospitals in the en...

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  • Diabetogenic effect of statins is difficult to ignore.
    Dr.Rajiv Kumar
    Authors mentioned, that meta-analysis include both published and unpublished data from randomised controlled trials (this remove bias of selective clinical trial reporting), and results were regardless of background statin or combination laropiprant therapy ( to maintain clarity, and or to remove confusion with regards to results). 34% higher risk of developing diabetes was reported with Niacin therapy and new-onset diabetes i...
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  • Diastolic function
    Philip A Smith

    Having scanned many a patient with pacemakers in the presence of new algorithms which allow significant AV delays (essentially P-R) prolongation, I have noticed that due to the timings, long P-R can cause truncation of diastolic filling time (E:A fusion). This will significantly impact the preload of the LV, reduce stroke volume and may even impact on coronary filling. I am unsure why this would increase the risk of AF bu...

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  • Revascularization of chronic total coronary occlusions
    Christophe Bauters

    Revascularization of chronic total coronary occlusions

    Christophe Bauters a, b, c, MD; Gilles Lemesle a, c, MD.

    a Centre Hospitalier R?gional et Universitaire de Lille, Lille, France b Inserm U1167, Institut Pasteur de Lille, Universit? de Lille 2, Lille, France c Facult? de M?decine de Lille, Lille, France

    To the Editor,

    We read with great interest the article by Ladwiniec et al. (1...

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  • Adiponectin and Atrial Fibrillation in Older Adults
    Jorge R Kizer

    We thank Dr. Kawada for his comments regarding our study. Consistent with the sexual dimorphism in circulating adiponectin levels documented in both rodents and humans, plasma concentrations of total and high-molecular -weight (HMW) adiponectin were higher in female than male participants in the Cardiovascular Health Study.[1] Despite such differences, we have not found evidence of effect modification by sex for total or H...

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  • Total and high molecular weight adiponectin are positively associated with incident atrial fibrillation by a follow-up study
    Tomoyuki Kawada

    I read with great interest the report by Macheret et al., (1) who conducted an 11-year prospective study in 3190 older adults, aged 65 years or older, without cardiovascular disease for monitoring incident atrial fibrillation (AF). The authors measured plasma total adiponectin, high molecular weight (HMW) adiponectin and amino-terminal pro-brain natriuretic peptide 1-76 (NT-proBNP1-76). There were 886 incident AF events,...

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  • Genomics in cardiology: new findings in old syndromes?
    Dilip Abraham

    Last year, in response to Priest and Ashley's paper on genomics in cardiology1, we urged close collaboration of congenital cardiologist and geneticist for some adults with congenital heart conditions, who had not been tested in childhood2. The converse is also pertinent. A recent case (23year old female) with chromosome 1p36 deletion* (previous PDA and VSD closure in childhood) presented at another hospital with TIA's;...

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  • Increasing professional and societal awareness of the uncertainty underpinning hypertrophic cardiomyopathy (HCM)
    Branavan Anandasundaram

    I read with great interest the above guidelines published for this rare inherited heart disorder. Over the past few years, much work has gone into elucidating possible risk factors and markers which can help predict sudden cardiac death in such patients. Namely, we have already established that myocardial fibrosis, age and certain mutations in cardiac genes are markers indicative of a higher risk of sudden cardiac death for t...

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