eLetters

752 e-Letters

  • Diastolic function
    Philip A Smith

    Having scanned many a patient with pacemakers in the presence of new algorithms which allow significant AV delays (essentially P-R) prolongation, I have noticed that due to the timings, long P-R can cause truncation of diastolic filling time (E:A fusion). This will significantly impact the preload of the LV, reduce stroke volume and may even impact on coronary filling. I am unsure why this would increase the risk of AF bu...

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  • Revascularization of chronic total coronary occlusions
    Christophe Bauters

    Revascularization of chronic total coronary occlusions

    Christophe Bauters a, b, c, MD; Gilles Lemesle a, c, MD.

    a Centre Hospitalier R?gional et Universitaire de Lille, Lille, France b Inserm U1167, Institut Pasteur de Lille, Universit? de Lille 2, Lille, France c Facult? de M?decine de Lille, Lille, France

    To the Editor,

    We read with great interest the article by Ladwiniec et al. (1...

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  • Adiponectin and Atrial Fibrillation in Older Adults
    Jorge R Kizer

    We thank Dr. Kawada for his comments regarding our study. Consistent with the sexual dimorphism in circulating adiponectin levels documented in both rodents and humans, plasma concentrations of total and high-molecular -weight (HMW) adiponectin were higher in female than male participants in the Cardiovascular Health Study.[1] Despite such differences, we have not found evidence of effect modification by sex for total or H...

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  • Total and high molecular weight adiponectin are positively associated with incident atrial fibrillation by a follow-up study
    Tomoyuki Kawada

    I read with great interest the report by Macheret et al., (1) who conducted an 11-year prospective study in 3190 older adults, aged 65 years or older, without cardiovascular disease for monitoring incident atrial fibrillation (AF). The authors measured plasma total adiponectin, high molecular weight (HMW) adiponectin and amino-terminal pro-brain natriuretic peptide 1-76 (NT-proBNP1-76). There were 886 incident AF events,...

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  • Genomics in cardiology: new findings in old syndromes?
    Dilip Abraham

    Last year, in response to Priest and Ashley's paper on genomics in cardiology1, we urged close collaboration of congenital cardiologist and geneticist for some adults with congenital heart conditions, who had not been tested in childhood2. The converse is also pertinent. A recent case (23year old female) with chromosome 1p36 deletion* (previous PDA and VSD closure in childhood) presented at another hospital with TIA's;...

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  • Increasing professional and societal awareness of the uncertainty underpinning hypertrophic cardiomyopathy (HCM)
    Branavan Anandasundaram

    I read with great interest the above guidelines published for this rare inherited heart disorder. Over the past few years, much work has gone into elucidating possible risk factors and markers which can help predict sudden cardiac death in such patients. Namely, we have already established that myocardial fibrosis, age and certain mutations in cardiac genes are markers indicative of a higher risk of sudden cardiac death for t...

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  • Re:Correspondence: A not so typical pericardial effusion case
    Rick A. Nishimura

    To the Editor:

    We have read over and agree with the insightful comments of Lazaros at al. Our clinical vignette mainly focused on the hemodynamic abnormalities and post-pericardiocentesis diagnosis. Therefore, some of the clinical details had to be omitted for purposes of brevity. A pericardial rub was present during our patient's initial evaluation, and she later developed chest pain consistent with pericardi...

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  • Re:The key role of the right ventricle in the pathogenesis of acute pulmonary oedema
    David M. Viau

    We thank Drs. MacIver and Clark for their comments regarding the role of the right ventricle in the development of acute pulmonary edema. We agree that a relative mismatch in stroke volume from the right and left sides of the heart can contribute to alveolar congestion [1]. Although we did mention preload as an important contributor to development of hypertensive acute heart failure (AHF), we chose to simplify the dis...

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  • Plasma N-terminal-pro-brain natriuretic peptide as a useful biomarker for predicting all-cause death in patients with heart failure regardless of the levels of left ventricular ejection fraction
    Tomoyuki Kawada

    I read with great interest the report by Kang et al., (1) who conducted one-year prospective study in 1670 patients with heart failure (HF). The authors measured plasma N-terminal-pro-brain natriuretic peptide (NT-proBNP), and left ventricular ejection fraction (LVEF) was used for binary classification of HF. Although patients with keeping LVEF showed significantly lower NT-proBNP level than those with reduced LVEF, all-...

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  • Habitual chocolate consumption and risk of cardiovascular disease among healthy men and women: Pre-determined research or/ "made-to-order" research ?
    Rajiv Kumar

    As a part of a low-fat diet regular consumption of chocolate (containing plant sterols [PS] and cocoa flavanols [CF] ) improve cardiovascular health by lowering cholesterol and improving blood pressure [1]. Exact mechanism remains uncertain. Chocolates are a rich source of catechins, a protective molecule against heart diseases, cancer, and other medical conditions. Catechin content highest in dark, bitter chocolate and l...

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