Abstract
The present paper reviews the evidence for a possible involvement of renal eicosanoids in the pathophysiology of high blood pressure in genetically hypertensive rats of the Lyon strain. Both in vivo and in vitro experiments suggest that an increased ability to synthesize the vasoconstrictor prostaglandin H2 and/or thromboxane A2 in renal vessels (1) acts as an autocrine amplifier of pressor agents and (2) may contribute to resetting the pressure natriuresis curve which is a prerequisite for the development and maintenance of hypertension.
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Benzoni D, Vincent M, Cuisinaud G, Sassard J. A new technique for the measurement of urinary 6-keto-prostaglandin Fla: Normal values in adults. Clin Chim Acta 126:283–289;1982.
Geoffroy J, Benzoni D, Sassard J. A new radioimmunoassay for urinary thromboxane B2 with prior purification by high performance liquid chromatography. Postaglandins Leukot Med 18:393–399;1985.
Geoffroy J, Benzoni D, Vincent M, Sassard J. Urinary prostaglandins and thromboxane B2 in genetically hypertensive rats of the Lyon strain. J Hypertens 3(suppl 4):S37-S39;1986.
Geoffroy J, Benzoni D, Vincent M, Sassard J. Thromboxane A2 and development of genetic hypertension in the Lyon rat strain. Hypertension 16:655–661;1990.
Liu KL, Benzoni D, Sassard J. Prostaglandin H2/Thromboxane A2 and renal functions in the Lyon hypertensive rat. Am J Physiol, in press.
Liu KL, Hadj-Aïssa A, Benzoni D, Sassard J. Renal thromboxane A2 synthesis in the Lyon hypertensive rat. Fundam Clin Pharmacol 6:345–351;1992.
Rettig R, Folberth CG, Graf C, Kopf D, Strauss H, Unger T. Post-transplantation hypertension in recipients of renal grafts from hypertensive donor rats. Clin Invest Med 14:492–498;1991.
Roman RJ, Allen W, Cowley AW Jr. Characterization of a new model for study of pressure-natriuresis in the rat. Am J Physiol 248:F190-F198;1985.
Vincent M, Sacquet J, Sassard J. The Lyon strains of hypertensive, normotensive and low-blood pressure rats. In: de Jong W, ed. Handbook of Hypertension. Amsterdam, Elsevier, vol 4, 314–327;1984.
Zhang BL, Sassard J. Eicosanoids-dependence of response of pre- but not postglomerular vessels to noradrenaline in rat isolated kidneys. Br J Pharmacol 110:235–238;1993.
Zipser R, Martin K. Urinary excretion of arterial blood prostaglandins and thromboxanes. Am J Physiol 242:E171-E177;1982.
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Sassard, J., Benzoni, D. Renal eicosanoids and blood pressure in genetically hypertensive rats of the lyon strain. J Biomed Sci 1, 201–203 (1994). https://doi.org/10.1007/BF02253302
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DOI: https://doi.org/10.1007/BF02253302