Hyperhomocysteinemia, hyperfibrinogenemia, and lipoprotein (a) excess in maintenance dialysis patients: a matched case-control study
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2019, American Journal of Kidney DiseasesCitation Excerpt :Second, it has been suggested that the renin-angiotensin system has a role in the pathogenesis of glaucoma through its effect on the production and drainage of aqueous humor.55 Third, CKD accelerates atherosclerosis,56,57 and atherosclerosis is known to be related to primary open angle glaucoma. Fourth, the progression of CKD enhances the generation of oxygen free radicals such as reactive oxygen species,58 for which accumulation has been proposed to be relevant in the pathogenesis of glaucoma.50,59
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2008, Kidney InternationalCitation Excerpt :We found that HCY had a modest impact on the association between CKD stages 3–5 and CAC. Although levels of HCY are elevated among pre-dialysis CKD vs non-CKD patients,23,24 less is known regarding the CVD risk associated with hyperhomocysteinemia in such subjects. Five previous studies examining the relationship between CKD and CAC did not include HCY as a covariate.12-16