EditorialHeme oxygenase: protective enzyme or portal hypertensive molecule?
References (33)
- et al.
The role of nitric oxide in the hyperdynamic circulatory syndrome associated with portal hypertension
J Hepatol
(1995) - et al.
Role of nitric oxide synthase 3 (eNOS) in the systemic vasodilation of portal hypertension
Gastroenterology
(2000) - et al.
Endogenous factors involved in the control of arterial tone in cirrhosis
J Hepatol
(1995) - et al.
Evidence for an endothelium-derived hyperpolarizing factor in the superior mesenteric artery from rats with cirrhosis
Hepatology
(2000) - et al.
Increased heme oxygenase activity in splanchnic organs from portal hypertensive rats: role in modulating mesenteric vascular reactivity
J Hepatol
(2001) - et al.
Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock
J Biol Chem
(1997) - et al.
Altered expression of heme oxygenase-1 in the livers of patients with portal hypertensive diseases
Hepatology
(2001) - et al.
Acute and chronic cyclooxygenase in portal-hypertensive rats: influence on nitric oxide biosynthesis
Gastroenterology
(1996) - et al.
Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility
J Clin Invest
(1999) - et al.
Nitric oxide: physiology, pathophysiology, and pharmacology
Pharmacol Rev
(1991)
Intracellular cyclic GMP receptor proteins
FASEB J
Signal transduction and regulation in smooth muscle
Nature
Regulation of myosin phosphatase by a specific interaction with cGMP-dependent protein kinase Iα
Science
K+ is an endothelium-derived hyperpolarizing factor in rat arteries
Nature
Old-timer makes a comeback
Nature
Cytochrome P450 2C is an EDHF synthase in coronary arteries
Nature
Cited by (16)
Peripheral vasculature in portal hypertension
2022, Cardio-Hepatology: Connections Between Hepatic and Cardiovascular DiseaseCardiovascular Complications of Cirrhosis
2012, Zakim and Boyer's HepatologyMolecular and Structural Basis of Portal Hypertension
2006, Clinics in Liver DiseaseCitation Excerpt :Portal hypertension–associated hyporeactivity to vasoconstrictors is caused mainly by NO (reviewed in [9–11]). The molecular mechanisms of NO-induced portal hypertensive SMC hyporesponsiveness are not well understood [10,20]. In normal SMC, NO stimulates soluble guanylyl cyclase to produce the second messenger, cyclic 3′,5′-guanosine monophosphate (cGMP) [22].
Clinical Consequences of Liver Disease: Cardiovascular
2006, Zakim and Boyer's HepatologyPortal hypertension produces an evolutive hepato-intestinal pro- and anti-inflammatory response in the rat
2005, CytokineCitation Excerpt :However, this would be detrimental because increased production of CO in splanchnic organs may contribute to the development and maintenance of an increased splanchnic blood flow and hyperdynamic circulation associated with PHT [66]. Therefore, in PHT, HO might be both a protective enzyme and a portal hypertensive molecule [67]. In relation to HO-2, the constitutive isoform of HO, the only chemical inducers identified are adrenal glucocorticoids [68].