Chest
Clinical Investigations: TechniquesClinical Significance of Myocardial Magnetic Resonance Abnormalities in Patients with Sarcoidosis: A 1-Year Follow-up Study
Section snippets
Study Population
Between October 1999 and September 2000, 20 patients with histologically proven, active sarcoidosis were referred for cardiac assessment. A diagnosis of sarcoidosis was confirmed if the clinical presentation and chest radiographic findings were supported by histologic evidence of noncaseous epithelioid granulomas by bronchial or salivary gland biopsy, and once the possibility of infection, environmental factors or medical treatment causing the granuloma had been eliminated. Other data collected
Clinical Data at Inclusion
The clinical findings concerning the 12 patients included in the study are summarized in Table 1. Eight patients had intrathoracic disease and the involvement of other organs. Two patients (patients 4 and 5) exhibited isolated intrathoracic involvement. One patient presented with Löfgren syndrome (patient 10), and one patient with myositis and intrathoracic involvement (patient 11). Sarcoidosis had been diagnosed only 1 year previously in seven patients, while disease duration ranged from 5 to
Discussion
The pathologic features of cardiac sarcoidosis include patchy infiltration of the myocardium with three successive histologic stages: edema, granulomatous infiltration, and fibrosis leading to postinflammatory scarring.2 MRI provides high-resolution information for both morphology and function, rendering MRI an effective method for the assessment of myocardial diseases. The ability of MRI to diagnose sarcoidal heart disease has been emphasized in several case reports,7,8,9,10,11,12 allowing
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