Chest
Clinical InvestigationsCatecholamine-induced Cardiomyopathy in Multiple Endocrine Neoplasia: A Histologic, Ultrastructural, and Biochemical Study
Section snippets
CASE REPORT
A 33-year-old man was admitted because of dyspnea on effort. He had suffered since childhood with dilatation of the stomach, megacolon, and bilateral megaloureter. At the age of 18 years, he had undergone left hemithyroidectomy because of a tumor. In the previous two years, he had developed a moderate hypertension, which was controlled by diuretics and serum converting enzyme inhibitors. At the time of admission, physical examination revealed a tall, slender, and hypotonic patient with enlarged
DISCUSSION
Bilateral pheochromocytomas have been observed in a patient with medullary thyroid carcinoma and mucosal neuromatosis of the tongue, stomach, and colon (megacolon), which is the typical configuration of multiple endocrine neoplasia, type 3.9 The major cardiovascular feature was a catecholamine-induced dilated cardiomyopathy, which is rare and has not been previously described in multiple endocrine neoplasia, type 3. At light microscopy, myocardial biopsy samples showed hypertrophy, with
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