Influence of serum triglyceride levels on the risk for myocardial infarction in 12,510 middle aged males: interaction with serum cholesterol

Atherosclerosis. 1999 Dec;147(2):243-7. doi: 10.1016/s0021-9150(99)00190-2.

Abstract

Objective: To study the influence of different levels of serum (s)-triglycerides in relation to s-cholesterol on the risk of myocardial infarction.

Design and subjects: A 6-13 (mean 10) year follow-up of 12,510 middle-aged men. Fasting s-triglycerides and s-cholesterol were measured at the screening examination.

Setting: Section of Preventive Medicine at the Department of Internal Medicine, Malmö General Hospital, an urban hospital for 240,000 inhabitants in southern Sweden.

Intervention: In minor groups of patients there were interventions addressing high lipid levels, high alcohol consumption, hypertension and glucose intolerance.

Main outcome measure: Myocardial infarction was used as an end-point.

Results: 446 myocardial infarctions occurred. The cumulative incidence rates were for the lowest triglyceride quartile 1.2%, for the second 3.2%, for the third 4.1% and for the highest 5.6%. After adjustment for age, year of screening, body mass index, diabetes, smoking, hypertension and s-cholesterol there was a significant relationship between triglycerides and the relative risk for myocardial infarction (P for trend=0.0087). For increasing levels of triglycerides, adjusted for the above factors except cholesterol, the impact of a certain cholesterol value for the occurrence of myocardial infarction was increased (P for trend=0.0092).

Conclusions: The present study emphasizes the interaction between cholesterol and triglyceride values for the risk of myocardial infarction. It is concluded that at triglyceride values above 1.0 mmol/l and cholesterol above 6.8 mmol/l there is an increasing interaction between cholesterol and triglyceride levels that might be of importance when evaluating the cardiovascular risk of middle aged men.

MeSH terms

  • Age Distribution
  • Cholesterol / blood*
  • Humans
  • Incidence
  • Logistic Models
  • Male
  • Mass Screening
  • Middle Aged
  • Myocardial Infarction / blood*
  • Myocardial Infarction / epidemiology*
  • Myocardial Infarction / etiology
  • Population Surveillance
  • Risk Assessment
  • Risk Factors
  • Sensitivity and Specificity
  • Sweden / epidemiology
  • Triglycerides / blood*

Substances

  • Triglycerides
  • Cholesterol