Proportion of fibrin and platelets differs in thrombi on ruptured and eroded coronary atherosclerotic plaques in humans

Heart. 2005 Apr;91(4):526-30. doi: 10.1136/hrt.2004.034058.

Abstract

Objective: To determine the proportion of platelets and fibrin in coronary thrombi.

Design: Immunohistochemical and morphometric means to examine the coronary arteries of 31 patients who died of acute myocardial infarction.

Results: Fresh thrombi were detected in the feeding arteries of infarction areas in 23 cases (74%) and were associated with plaque rupture in 18 (78%) and plaque erosion in 5 (22%). An immunohistochemical study showed that the thrombi consisted of a mixture of fibrin and platelets as well as some other types of blood cells. The fibrin and platelet positive areas in the thrombi associated with plaque rupture accounted for 74 (19)% and 35 (20)% (p < 0.01) and those associated with erosion accounted for 51 (6)% and 70 (21)%, respectively, of the total areas. Areas of positive immunoreactivity for tissue factor and C reactive protein were also significantly greater in ruptured than in eroded plaques.

Conclusion: These results indicate that the proportions of fibrin and of platelets differ in coronary thrombi on ruptured and eroded plaques. Higher proportions of tissue factor and C reactive protein contribute more significantly to thrombus formation on plaque rupture than on plaque erosion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers / analysis
  • Blood Platelets / pathology*
  • C-Reactive Protein / analysis
  • Coronary Artery Disease / metabolism*
  • Coronary Artery Disease / pathology
  • Coronary Thrombosis / metabolism*
  • Coronary Thrombosis / pathology
  • Female
  • Fibrin / analysis*
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Thromboplastin / analysis

Substances

  • Biomarkers
  • Fibrin
  • C-Reactive Protein
  • Thromboplastin