In this article we describe global cardiovascular risk factor trends in women, both physiological and behavioral, in order to improve the understanding of cardiovascular health of women. Our aim in presenting this information is to inform interventions and policies to improve the cardiovascular health of women. Although differences are apparent between developing and developed countries, a range of commonalities exist that allow a global approach to improving women's health. A multifaceted approach considering physiological, social, economic, and political determinants is critical to improve the cardiovascular health outcomes of women.