The occurrence of fresh thrombus during percutaneous coronary interventions, especially in patients with diffusely diseased saphenous vein bypass grafts is associated with an increased incidence of procedural complications and clinical events. The AngioJet Rapid Thrombectomy Catheter was designed to remove thrombus via a Bernoulli effect induced vacuum. Here we report on the technical aspects of the device and the AngioJet thrombectomy procedure. Indications and potential complications, both procedure- and device related are discussed.