PT  - JOURNAL ARTICLE
AU  - M Ni
AU  - W Q Chen
AU  - Y Zhang
TI  - Animal models and potential mechanisms of plaque destabilisation and disruption
AID  - 10.1136/hrt.2008.143461
DP  - 2009 Sep 01
TA  - Heart
PG  - 1393--1398
VI  - 95
IP  - 17
4099  - http://heart.bmj.com/content/95/17/1393.short
4100  - http://heart.bmj.com/content/95/17/1393.full
SO  - Heart2009 Sep 01; 95
AB  - Studies of the pathophysiological mechanism of both acute coronary syndromes and plaque stabilising treatment are driving the development of animal models of vulnerable plaque. In contrast to advances in human studies of pathology, the definition, criteria and classification of vulnerable and ruptured plaques in animal models are still in dispute. Many approaches to increasing the intrinsic vulnerability of plaques or extrinsic forces on plaques have been reported. However, an ideal animal model mimicking human plaque rupture is still lacking, and the exact cellular and molecular mechanisms of plaque progression are not fully understood. This review summarises current progress in animal model studies related to plaque destabilisation and disruption and the possible mechanisms involved.