RT Journal Article
SR Electronic
T1 Animal models and potential mechanisms of plaque destabilisation and disruption
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 1393
OP 1398
DO 10.1136/hrt.2008.143461
VO 95
IS 17
A1 M Ni
A1 W Q Chen
A1 Y Zhang
YR 2009
UL http://heart.bmj.com/content/95/17/1393.abstract
AB Studies of the pathophysiological mechanism of both acute coronary syndromes and plaque stabilising treatment are driving the development of animal models of vulnerable plaque. In contrast to advances in human studies of pathology, the definition, criteria and classification of vulnerable and ruptured plaques in animal models are still in dispute. Many approaches to increasing the intrinsic vulnerability of plaques or extrinsic forces on plaques have been reported. However, an ideal animal model mimicking human plaque rupture is still lacking, and the exact cellular and molecular mechanisms of plaque progression are not fully understood. This review summarises current progress in animal model studies related to plaque destabilisation and disruption and the possible mechanisms involved.