PT  - JOURNAL ARTICLE
AU  - R Anantharaman
AU  - M Heatley
AU  - C F M Weston
TI  - Hyperglycaemia in acute coronary syndromes: risk-marker or therapeutic target?
AID  - 10.1136/hrt.2008.146027
DP  - 2009 May 01
TA  - Heart
PG  - 697--703
VI  - 95
IP  - 9
4099  - http://heart.bmj.com/content/95/9/697.short
4100  - http://heart.bmj.com/content/95/9/697.full
SO  - Heart2009 May 01; 95
AB  - Patients with acute coronary syndrome (ACS) often have raised blood glucose concentrations when admitted to hospital; a marker for poorer prognosis. Interventions to rapidly normalise blood glucose inconsistently are applied and with uncertain utility. Here we review the association of hyperglycaemia with outcome, present evidence that this hyperglycaemia reflects more than a pre-existing diabetic state and discuss mechanisms by which glucose may adversely affect the course of acute myocardial infarction (AMI). Finally, we seek evidence that intensive insulin treatment improves outcome.