RT Journal Article
SR Electronic
T1 A straightforward guide to the basic science behind arrhythmogenesis
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 1907
OP 1915
DO 10.1136/heartjnl-2014-305647
VO 100
IS 24
A1 Berengere M Dumotier
YR 2014
UL http://heart.bmj.com/content/100/24/1907.abstract
AB The underlying mechanisms behind cardiac arrhythmias are described in this manuscript. In clinical practice, significant arrhythmias are unpredictable, and under some conditions, potentially life-threatening. How can basic science help improve our understanding of molecular entities and factors behind the arrhythmia to advance, develop, adapt or deliver available medications? Structural heart disease and remodelling (eg, heart failure, cardiomyopathy), the presence of modulating factors (ie, diabetes mellitus, autonomic nervous system), genetic predispositions (ie, channelopathies) are considerable preconditions, and influence the development of an arrhythmia. Cardiac arrhythmias may indeed share common basic mechanisms, while elements and substrates perpetuating these may be different and ultimately manifest as various ECG abnormalities. This article lists cellular and subcellular iatrogenic disorders responsible for abnormal impulse generation, or conduction disturbances, including the latest development in theories and biological research, for a better understanding of cellular disorders behind arrhythmogenesis.