Diagnostic value of NT-proBNP for the detection of a left ventricular ejection fraction of ≤ 40%
| All patients (n=2193) | Any symptoms or signs of CHF (n=928) | |
|---|---|---|
| The cut off value for NT-proBNP was defined as the 85th centile of subjects with an LVEF of > 50% (357 pmol/l). | ||
| *Area under the curve in a receiver operating characteristic curve. | ||
| CHF, chronic heart failure; LVEF, left ventricular ejection fraction; NT-proBNP, N-terminal pro-brain natriuretic peptide. | ||
| Sensitivity | 73% | 78% |
| Specificity | 82% | 76% |
| Positive predictive value | 24% | 30% |
| Negative predictive value | 98% | 96% |
| AUC* | 0.85 | 0.84 |
| Prevalence of LVEF ≤40% | 7% | 12% |