Patient clinical characteristics and profiles of endothelin-1, C-terminal fragment, and neutral endopeptidase 24.11
| Risk factors | Group 1A (n=30) | Group 1B (n=28) | Group 2A (n=24) | Group 2B (n=18) |
|---|---|---|---|---|
| Values are mean (SD) unless otherwise indicated | ||||
| *p<0.001 among 4 groups via ANOVA | ||||
| **p<0.05 among 4 groups via ANOVA | ||||
| †p<0.01 among 4 groups via ANOVA | ||||
| ‡Baseline versus 10 minutes. | ||||
| Age (years) | 58 (12) | 59 (14) | 55 (16) | 56 (18) |
| Males | 18 (60%) | 16 (59%) | 15 (62%) | 12 (66%) |
| Hypertension | 8 (27%) | 6 (21%) | 4 (17%) | 3 (17%) |
| Diabetes mellitus | 3 (10%) | 2 (7%) | 2 (8%) | 2 (11%) |
| Smoking | 12 (40%) | 10 (36%) | 10 (42%) | 8 (44%) |
| Hyperlipidemia | 2 (7%) | 1 (4%) | 1 (4%) | 1 (6%) |
| Haemoglobin (g/dl) | 13.0 (1.8) | 13.1 (1.7) | 13.4 (1.7) | 13.3 (2.0) |
| Leucocyte (×1000)* | 9.7 (2.5) | 9.8 (2.6) | 7.1 (1.8) | 6.9 (1.8) |
| Neutrophil (%) | 67 (11) | 66 (12) | 64 (13) | 64 (13) |
| Monocyte (%) | 7.4 (3.0) | 7.5 (2.9) | 7.9 (3.5) | 6.2 (3.4) |
| Platelet (×1000) | 272 (86) | 270 (84) | 266 (88) | 270 (90) |
| NYHA functional class | ||||
| Class I | 0 | 0 | 24 (100%) | 18 (100%) |
| Class II | 0 | 0 | 0 | 0 |
| Class III | 22 (73%) | 20 (71%) | 0 | 0 |
| Class IV | 8 (27%) | 8 (29%) | 0 | 0 |
| LVEF (echocardiography)** | 22 (8) | 22 (10) | 62 (10) | 64 (12) |
| LVEF (ventriculography) | 20 (6) | 21 (8) | ||
| Endothelin-1 (pmol/l) | ||||
| Baseline* | 3.2 (0.8) | 3.3 (0.8) | 1.7 (0.6) | 1.6 (0.5) |
| 10 min* | 1.9 (0.7) | 3.4 (0.9) | 1.6 (0.6) | 1.5 (0.6) |
| Difference (95% CI)† | 1.3 (0.9 to 1.7) | 0.1 (0 to 0.5) | 0.1 (0 to 0.4) | 0.1 (0 to 0.3) |
| p Value‡ | <0.001 | 0.71 | 0.73 | 0.78 |
| C-terminal peptide (pmol/l) | ||||
| Baseline* | 0.9 (0.3) | 0.9 (0.4) | 0.2 (0.3) | 0.2 (0.2) |
| 10 min* | 1.9 (0.6) | 0.9 (0.5) | 0.4 (0.4) | 0.3 (0.3) |
| Difference (95% CI)† | 1.0 (0.6 to 1.4) | 0.1 (0 to 0.3) | 0.2 (0 to 0.4) | 0.1 (0 to 0.2) |
| p Value‡ | <0.001 | 0.83 | 0.65 | 0.55 |
| NEP (nmol/mg protein) | ||||
| Baseline* | 5.22 (1.40) | 5.28 (1.50) | 4.76 (1.38) | 4.42 (1.68) |
| 10 min* | 9.44 (1.68) | 5.18 (1.70) | 8.54 (1.88) | 4.56 (1.92) |
| Difference (95% CI)† | 4.21 (3.58 to 4.92) | 0.10 (0 to 0.90) | 3.78 (2.99 to 4.57) | 0.14 (0 to 1.04) |
| p Value‡ | <0.001 | 0.27 | <0.001 | 0.64 |