Patient demographics and characteristics at baseline
| Unstable angina | Stable angina | |||
|---|---|---|---|---|
| Fluvastatin (n = 417) | Placebo (n = 407) | Fluvastatin (n = 418) | Placebo (n = 416) | |
| *Percutaneous coronary intervention (PCI) categories are not mutually exclusive; hence, percentage values may not total 100%. | ||||
| AHA, American Heart Association; BMI, body mass index; BP, blood pressure; CCS, Canadian Cardiovascular Society; HDL, high density lipoprotein; IHD, ischaemic heart disease; LDL, low density lipoprotein; MI, myocardial infarction; NA, not applicable. | ||||
| Age (years) | 60.7 (10.2) | 60.2 (9.9) | 59.5 (10.0) | 59.8 (9.8) |
| Men | 344 (82.5%) | 336 (82.6%) | 360 (86.1%) | 350 (84.1%) |
| BMI (kg/m2) | 26.9 | 26.3 | 26.5 | 26.5 |
| Risk factors | ||||
| Smoking (previous and current) | 303 (72.7%) | 297 (73.0%) | 293 (70.1%) | 288 (69.2%) |
| Diabetes | 65 (15.6%) | 34 (8.4%) | 55 (13.2%) | 48 (11.5%) |
| Hypertension | 157 (37.6%) | 158 (38.8%) | 169 (40.4%) | 157 (37.7%) |
| Family history of IHD | 113 (27.4%) | 119 (29.3%) | 125 (30.0%) | 131 (31.7%) |
| Previous MI | 184 (44.1%) | 172 (42.3%) | 179 (42.8%) | 192 (46.2%) |
| Previous stroke | 10 (2.4%) | 21 (5.2%) | 7 (1.7%) | 6 (1.4%) |
| Multivessel disease | 148 (35.5%) | 138 (339%) | 170 (40.7%) | 149 (35.8%) |
| Braunwald classification | ||||
| IB | 53 (12.7%) | 49 (12.0%) | NA | NA |
| IIB | 186 (44.6%) | 195 (47.9%) | NA | NA |
| IIIB | 82 (19.7%) | 79 (19.4%) | NA | NA |
| IC | 11 (2.6%) | 10 (2.5%) | NA | NA |
| IIC | 49 (11.8%) | 34 (8.4%) | NA | NA |
| IIIC | 36 (8.6%) | 40 (9.8%) | NA | NA |
| CCS classification (%) | ||||
| I | NA | NA | 44 (10.5%) | 45 (10.8%) |
| II | NA | NA | 180 (43.1%) | 161 (38.7%) |
| III | NA | NA | 99 (23.7%) | 101 (24.3%) |
| IV | NA | NA | 23 (5.5%) | 18 (4.3%) |
| Silent ischaemia | NA | NA | 72 (17.2%) | 91 (21.9%) |
| Baseline lipid concentration (mmol/) | ||||
| Total cholesterol | 5.17 (0.81) | 5.16 (0.84) | 5.19 (0.80) | 5.17 (0.87) |
| LDL cholesterol | 3.43 (0.75) | 3.42 (0.79) | 3.40 (0.76) | 3.42 (0.80) |
| HDL cholesterol | 0.95 (0.28) | 0.95 (0.26) | 1.00 (0.34) | 0.98 (0.33) |
| Triglycerides | 1.75 (0.68) | 1.75 (0.71) | 1.75 (0.87) | 1.71 (0.73) |
| Systolic BP (mm Hg) | 128 | 127 | 129 | 130 |
| Diastolic BP (mm Hg) | 74 | 75 | 76 | 76 |
| Ejection fraction (%) | 62.0 | 62.9 | 62.7 | 60.8 |
| Lesion type (AHA class) | ||||
| A | 20.3% | 18.6% | 19.4% | 20.1% |
| B1 | 34.1% | 35.6% | 35.3% | 35.9% |
| B2 | 36.5% | 36.2% | 30.5% | 29.6% |
| C | 9.1% | 9.6% | 14.8% | 14.4% |
| Type of PCI* | ||||
| Balloon only | 37.6% | 38.7% | 46.0% | 44.8% |
| Stent | 61.7% | 58.8% | 50.9% | 52.3% |
| Others | 3.4% | 4.5% | 4.4% | 5.1% |