Baseline values and differences in means for the last three measurements compared with baseline values in various parameters
| Parameters | Alive (n = 25) | PHF (n = 4) | SUD (n = 5) | p Value (alive v PHF) | p Value (alive v SUD) |
|---|---|---|---|---|---|
| Single baseline value | |||||
| LVEF (%) | 29 (1.2) | 26 (5.5) | 27 (4) | 0.8 | 0.7 |
| Furosemide (mg/day) | 61 (10.8) | 56 (17.50 | 40 (14) | 0.8 | 0.3 |
| Triangular index | 38 (2.6) | 31 (6) | 46 (5.6) | 0.34 | 0.24 |
| SDNN (ms) | 142 (9) | 114 (17) | 173 (20) | 0.26 | 0.16 |
| MHR (beats/min) | 70.6 (2.9) | 64 (4.8) | 70.8 (5.3) | 0.4 | 0.98 |
| Ventricular extrasystoles | 1606 (356) | 2116 (1267) | 1008 (427) | 0.63 | 0.96 |
| NSVT events/patient | 0.4 (0.12) | 4.7 (2.8) | 0.2 (0.17) | 0.001 | 0.8 |
| Plasma potassium (mmol/l) | 5.01 (0.7) | 5.4 (0.3) | 5.06 (0.8) | 0.27 | 0.89 |
| Plasma creatinine (mmol/l) | 127 (8) | 145 (28) | 134 (17) | 0.48 | 0.71 |
| Plasma BNP (pg/ml) | 61 (9.9) | 48 (26) | 93 (20.9) | 0.38 | 0.14 |
| Plasma aldosterone (pg/ml) | 142 (26) | 102 (45) | 271 (116) | 0.68 | 0.22 |
| Plasma WBC (109/l) | 6.9 (0.42) | 7.9 (0.49) | 5.9 (0.49) | 0.25 | 0.32 |
| Plasma neutrophil (109/l) | 4.1 (0.3) | 5.6 (0.8) | 3.7 (0.79) | 0.07 | 0.59 |
| C reactive protein (μg/ml) | 4.2 (0.6) | 13 (5) | 7 (3.9) | 0.02 | 0.72 |
| Last three measures | Intraindividual changes from baseline between PHF and alive patients | Intraindividual changes from baseline between SUD and alive patients | |||
|---|---|---|---|---|---|
| Data are mean (SEM). | |||||
| Some data are borderline between being normally distributed and not being normally distributed. For those parameters, the data are presented and analysed in two ways (logarithmically transformed and not transformed). | |||||
| *Only one baseline value available for C reactive protein. | |||||
| BNP, brain natriuretic peptide; MHR, maximum heart rate; NSVT, non-sustained ventricular tachycardia; PHF, progressive heart failure; SDNN, standard deviation of all NN intervals; SUD, sudden unexpected death; WBC, white blood cells. | |||||
| 24 hour triangular index | −11.4 (3.9) | −11.3 (3.5) | 0.023 | 0.01 | |
| 24 hour SDNN (ms) | −51 (13.4) | −36.8 (11.8) | 0.002 | 0.013 | |
| 24 hour MHR (beats/min) | +14 (5.6) | −4.4 (4.9) | 0.04 | 0.25 | |
| 24 hour ventricular extrasystoles | +6293 (964) | +812 (850) | 0.0001 | 0.225 | |
| 24 hour log ventricular extrasystoles | +1 (0.36) | +0.17 (0.3) | 0.028 | 0.59 | |
| NSVT events/patient | +48 (14) | +0.04 (12) | 0.002 | 0.99 | |
| Plasma BNP (pg/ml) | +81.6 (22) | −13.5 (19.5) | 0.003 | 0.49 | |
| Log plasma BNP | +0.45 (0.17) | −0.03 (0.15) | 0.044 | 0.84 | |
| Plasma aldosterone (pg/ml) | +183 (50) | 7.7 (44) | 0.003 | 0.86 | |
| Log plasma aldosterone | +0.43 (0.12) | +0.02 (0.11) | 0.005 | 0.82 | |
| Plasma creatinine (mmol/l) | −1.8 (16) | −11 (13) | 0.339 | 0.91 | |
| Plasma neutrophil (109/l) | +2.3 (0.62) | +1.5 (0.55) | 0.003 | 0.026 | |
| C reactive protein (μg/ml)* | +9 (2.6) | +5 (2.3) | 0.001 | 0.04 | |
| Log C reactive protein* | +0.11 (0.13) | +0.26 (0.12) | 0.39 | 0.039 | |