Patients without, with transient, and with persistent microvascular dysfunction after recanalisation of a chronic total coronary occlusion
| Microvascular dysfunction | p Value | |||
|---|---|---|---|---|
| None | Transient | Persistent | ||
| Data are mean (SD). p Values represent the results of the ANOVA. | ||||
| Six patients with reocclusion at follow up are excluded. | ||||
| Comparison with other groups (post hoc analysis): *p<0.01, **p<0.001; changes within a group during follow up: †p<0.05, ††p<0.005, †††p<0.001. | ||||
| APV, average peak velocity; CFVR, coronary flow velocity reserve; FFR, fractional flow reserve; LV, left ventricular; LVEF, left ventricular ejection fraction; MI, myocardial infarction; WMSI, wall motion severity index. | ||||
| Number of patients | 52 | 29 | 17 | |
| Age (years) | 61.6 (9.5) | 65.2 (8.2) | 65.7 (12.7) | 0.16 |
| Prior MI | 67% | 59% | 76% | 0.47 |
| Diabetes | 13%* | 41% | 59% | <0.001 |
| Hypertension | 71% | 90% | 76% | 0.15 |
| FFR | 0.87 (0.07) | 0.86 (0.09) | 0.87 (0.09) | 0.91 |
| Diameter restenosis (%) | 49 (19) | 47 (21) | 43 (17) | 0.46 |
| Coronary haemodynamic variables at baseline | ||||
| Basal APV (cm/s) | 25.1 (12.1)** | 35.0 (12.6) | 40.7 (18.8) | <0.001 |
| Hyperaemic APV (cm/s) | 59.8 (26.9) | 54.6 (21.5) | 58.0 (25.4) | 0.72 |
| CFVR | 2.44 (0.39)** | 1.57 (0.26) | 1.46 (0.21) | <0.001 |
| Coronary haemodynamic variables at follow up | ||||
| Basal APV (cm/s) | 21.5 (7.3)† | 23.5 (9.9)††† | 40.9 (19.7)** | <0.001 |
| Hyperaemic APV (cm/s) | 57.1 (19.4) | 61.1 (24.9) | 66.9 (40.2) | 0.39 |
| CFVR | 2.78 (0.76)†† | 2.67 (0.60)††† | 1.58 (0.31)** | <0.001 |
| LV function at baseline | ||||
| LVEF | 0.60 (0.17) | 0.60 (0.20) | 0.52 (0.21) | 0.29 |
| WMSI (SD/chord) | −1.86 (1.33) | −1.86 (1.33) | −2.64 (1.27) | 0.09 |
| Wall motion extension (chords) | 12 (12) | 12 (11) | 19 (12) | 0.08 |
| LV function at follow up | ||||
| LVEF | 0.67 (0.14)††† | 0.70 (0.13)†† | 0.57 (0.24)*† | 0.03 |
| WMSI (SD/chord) | −1.28 (1.32)††† | −0.78 (0.95)††† | −2.05 (1.50)*† | 0.06 |
| Wall motion extension (chords) | 8 (12)†† | 4 (9)††† | 15 (16)* | 0.01 |