The new biology of aldosterone
| • Aldosterone synthesis is widespread in the body outside of the adrenal cortex |
| • Aldosterone receptors are widespread in the body as well as traditional renal receptors |
| • Aldosterone produces endothelial vascular dysfunction |
| • Aldosterone produces tissue injury and fibrosis—seen in the myocardium, kidney, and cerebral tissues |
| • Aldosterone produces baroreceptor dysfunction |