Haffner 1998, Register Finnish6 | 69 v 890 | 58 years | Incidence of MI | CV mortality 15.9% v 15.4%, p<0.001 | Lack of power to detect differences between the two groups |
45% F | 8 years | 18.8% v 20.2%, p<0.001 |
Type 2 DM | 1982–1990 | Incidence of stroke 7.2% v 10.3%, p<0.001 | HR for mortality 1.2 (95% CI 0.6 to 2.4), p = 0.5 between D+ v D− |
Simons 1998, Prospective Australia7 | 478 v 130 | 70 years | Incidence of CHD | NR | |
48% F | NR | 52.7% v 31.5%, p NR |
Type 1 + 2 DM | 8.2 years | HR 0.67 (95% CI 0.46 to 0.97), p<0.04, D+ CHD− v D− CHD+ |
Hu 2001, Prospective USA8 | 1302 v 3705 | 62 years | NR | Total mortality RR* 2.58 v 2.44 | Women who were D+ >15 years were similar with prior CHD |
100% nurses | NR | CV mortality RR* 7.46 v 4.86 |
Type 2 DM | 1976–1996 | Fatal CHD RR* 10.7 v 5.65 |
| | | | | |
Lotufo 2001, Prospective PHS,USA9 | 5906 v 2317 | 62 years | NR | Total mortality RR* 2.2 v 2.3 | DM+ CHD+ identifies a high risk group |
100% M | NR | CHD mortality RR* 5.6 v 3.3 |
Type DM NR | 5 years |
| | | | | |
Evans 2002 Transversal cohort studies Scotland10 | Transversal | 57 years | Hospitalisation for MI | Total mortality RR 1.33 | Increased risk with male sex for total death and age for total and CV death in the 2 studies |
1347 v 1155 | 6 years | Transversal | D− MI+ v D+ MI− |
42% F | 1988–1995 | RR 2.27 DM− MI+ v DM+ MI− |
Type 2 DM | 66 years | Cohort | Total mortality RR 1.35 |
Cohort | RR 3.10 DM− MI+ v DM+ MI− | D− MI+ v D+ MI− |
7414 v 3977 | | CV mortality RR 2.93 |
49% F | | D− MI+ v D+ MI− |
| | | | | |
Cho 2002, HPFS USA11 | 2038 v 230 | 61 years | NR | Total mortality RR* 2.07 v 1.76 | Duration of DM independent risk factors for total and CHD death |
100% M | 0–26 years | | CV mortality RR* 5.51 v 2.75 |
Type 2 DM | 10 years | | Fatal CHD RR* 8.39 v 3.37 |
| | | | | |
Becker 2003, Register Dutch12 | 234 v 208 | 62 years | Men HR* 7.1 D− CVD+ | Fatal event | Women DM+ CVD− have a risk of CV event and death similar with women DM− CVD+ |
48% F | 6.4 years | HR* 4.0 D+ CVD− | Men HR* 2.4 D− CVD+ |
Type 2 DM | 1989–2000 | Women HR* 3.5 D− CVD+ | HR* 1.2 D+ CVD− |
HR* 4.0 D+ CVD− | Women HR* 2.6 D− CVD+ |
| HR* 5.1 D+ CVD- |
| | | | | |
Lee 2004, Prospective, ARIC USA13 | 283 v 1460 | 45–64 years | NR | Fatal CHD + non-fatal MI | Same results when newly diagnosed DM (self reported) at baseline are included |
% F NR | NR | RR 1.86 D− MI+ v D+ MI− |
Type 2 DM | 9 years | Fatal + non-fatal stroke |
RR 1.05 D− MI+ v D+ MI− |
CV mortality |
RR 1.82 D− MI+ v D+ MI− |
| | | | | |
Wannamethee 2004, Prospective UK5 | 547 v 202 | 63 years | Incidence CHD events | Total mortality D− MI+ v D+ MI− RR 1.25 (95% CI 0.94 to 1.67) CHD mortality D− MI+ v D+ MI− | Increased CHD events and death with duration of DM >12 years |
100% M Type DM NR | NR 10 years | 19% D+ CHD− v 19.9% D−Angina+ v |
| | 30% D− MI+ | RR 1.47 (95% CI 0.94 to 2.29) |
RR D− MI+ v D+ MI− | |
CHD event 1.59, stroke 0.87 | |