Geometric means and the IQR for biochemical and physiological variables by CAD status in males and females separately and together; the ratios of the means in patients with CAD relative to those without CAD; the values predicted from the fitted regression models for patients with and without CAD; and the corresponding adjusted ratios with their 95% CI.
| Risk factor (number missing) | CAD status | Geometric mean (IQR) | Males and females | *Adjusted | |||||
|---|---|---|---|---|---|---|---|---|---|
| Males | Females | Geometric mean | Ratio | †p Value | ‡Adjusted mean | Ratio (95% CI) | †p Value | ||
| *Adjusted for sex, age and smoking status (never smoked, ex-smoker or current smoker); †p values are given for the tests of differences between both the unadjusted and adjusted means; ‡means estimated from the fitted models for male patients, who have never smoked at 49 years of age. | |||||||||
| Total cholesterol (mmol/l) | CAD | 6.21 (5.4–7.2) | 6.72 (5.9–7.4) | 6.38 | 0.93 | <0.001 | 6.29 | 0.97 (0.93–1.02) | 0.22 |
| No CAD | 6.54 (6.0–7.2) | 7.14 (6.2–8.2) | 6.88 | 6.47 | |||||
| LDL (mmol/l) | CAD | 4.14 (3.5–5.0) | 4.45 (3.7–5.3) | 4.24 | 0.90 | <0.001 | 4.26 | 0.95 (0.90 to 1.02) | 0.14 |
| No CAD | 4.58 (4.0–5.3) | 4.92 (4.0–5.9) | 4.77 | 4.46 | |||||
| HDL (mmol/l) | CAD | 1.24 (1.1–1.5) | 1.37 (1.2–1.6) | 1.28 | 0.92 | 0.004 | 1.21 | 0.94 (0.89 to 0.99) | 0.03 |
| No CAD | 1.23 (1.1–1.4) | 1.51 (1.3–1.8) | 1.39 | 1.29 | |||||
| Triglycerides (mmol/l) | CAD | 1.44 (1.1–1.9) | 1.45 (1.1–2.1) | 1.44 | 1.16 | 0.001 | 1.33 | 1.08 (0.97 to 1.19) | 0.16 |
| No CAD | 1.27 (0.9–1.6) | 1.22 (0.9–1.7) | 1.24 | 1.24 | |||||
| Apolipoprotein A 1 (g/l) | CAD | 1.34 (1.2–1.6) | 1.43 (1.2–1.7) | 1.37 | 1.00 | 0.88 | 1.33 | 1.01 (0.96 to 1.06) | 0.74 |
| No CAD | 1.27 (1.1–1.4) | 1.45 (1.3–1.7) | 1.37 | 1.32 | |||||
| Apolipoprotein B (g/l) | CAD | 1.17 (1.0–1.4) | 1.33 (1.1–1.6) | 1.22 | 0.94 | 0.08 | 1.21 | 1.01 (0.94 to 1.09) | 0.76 |
| No CAD | 1.23 (1.1–1.5) | 1.34 (1.1–1.6) | 1.29 | 1.20 | |||||
| Systolic blood pressure (mm Hg)10 | CAD | 128.3 (117–140) | 135.5 (120–158) | 130.7 | 1.05 | <0.001 | 126.3 | 1.00 (0.97 to 1.03) | 0.80 |
| No CAD | 125.4 (118–135) | 123.4 (110–135) | 124.3 | 125.8 | |||||
| Diastolic blood pressure (mm Hg)10 | CAD | 78.3 (70–89) | 79.0 (70–89) | 78.6 | 1.02 | 0.12 | 76.3 | 0.99 (0.95 to 1.02) | 0.37 |
| No CAD | 77.4 (70–80) | 76.4 (70–84) | 76.8 | 77.4 | |||||
| Homocysteine (μmol/l) | CAD | 11.40 (9.5–13.2) | 11.84 (9.8–14.5) | 11.55 | 1.09 | 0.006 | 11.05 | 1.03 (0.96 to 1.10) | 0.47 |
| No CAD | 11.01 (8.9–12.4) | 10.32 (8.5–12.3) | 10.60 | 10.77 | |||||
| Fibrinogen (g/l) | CAD | 3.04 (2.4–3.8) | 3.18 (2.7–3.7) | 3.09 | 1.11 | 0.001 | 2.81 | 1.03 (0.97 to 1.10) | 0.34 |
| No CAD | 2.64 (2.2–3.1) | 2.88 (2.3–3.5) | 2.78 | 2.72 | |||||
| Plasminogen activator inhibitor-1 (IU/ml) | CAD | 10.50 (6.8–18.8) | 9.75 (4.9–17.2) | 10.2 | 1.22 | 0.01 | 9.83 | 1.03 (0.87 to 1.22) | 0.73 |
| No CAD | 9.83 (6.2–18.9) | 7.49 (4.1–12.8) | 8.4 | 9.54 | |||||
| White blood cells (number/nl)1 | CAD | 6.16 (5.4–7.2) | 6.54 (5.3–8.0) | 6.29 | 1.05 | 0.10 | 5.85 | 1.05 (0.99 to 1.11) | 0.13 |
| No CAD | 5.85 (5.0–6.8) | 6.14 (5.1–7.5) | 6.02 | 5.60 | |||||
| Haematocrit1 | CAD | 0.44 (0.42–0.46) | 0.40 (0.39–0.42) | 0.43 | 1.02 | 0.07 | 0.44 | 0.99 (0.98 to 1.01) | 0.35 |
| No CAD | 0.44 (0.43–0.46) | 0.40 (0.39–0.42) | 0.42 | 0.44 | |||||
| Glucose (mmol/l) | CAD | 5.12 (4.7–5.5) | 4.97 (4.6–5.4) | 5.07 | 1.05 | <0.001 | 5.00 | 1.00 (0.98 to 1.03) | 0.87 |
| No CAD | 5.00 (4.7–5.3) | 4.71 (4.3–5.1) | 4.83 | 4.99 | |||||