Abstract 027
| Parameters | High Fat 4 weeks | iNOS KO 4 weeks | P | High Fat 8 weeks | iNOS KO 8 weeks | P |
|---|---|---|---|---|---|---|
| [Table; Mean±SEM; N.S– not significant] | ||||||
| Weight (grams) | 29.01±0.4 | 27.92±0.5 | N.S | 38.46±0.58 | 35.65±1.32 | N.S |
| Epididymal Fat Pad (mg) | 24.37±1.5 | 23.45±0.7 | N.S | 33.58±0.89 | 32.07±1.06 | N.S |
| Systolic BP (mm Hg) | 122.9±0.4 | 122.5±0.9 | N.S | 124.8±0.7 | 124.0±0.7 | N.S |
| Fasting glucose (mM) | 12.1±0.3 | 7.7±0.2 | <0.01 | 10.1±0.4 | 8.5±0.4 | <0.01 |
| % Fall in blood sugar at 30 mins after ITT | 54.98±0.6 | 68.1±2.6 | <0.01 | 48.45±3.3 | 68.1±1.2 | <0.01 |
| % Change in PE E-max after LNMMA | 86.4±11.7 | 51.3±9.5 | <0.01 | 135 ±13.2 | 57.7±21.0 | <0.01 |
| % Change in PE E-max after insulin | −28.6±11 | −48.6±3.8 | <0.01 | +11.2±15.5 | −20.5±7.7 | <0.01 |
| % Change in PE E-max after catalase | −19.6±4.1 | −22.9±5.2 | N.S | −14.9±3.8 | −15.3±2.8 | N.S |