Baseline characteristics of cases and controls
| Variable | Cases (n = 483) | Controls (n = 1107) | p Value | Original study cohort (n = 6595) |
|---|---|---|---|---|
| Values are mean (SD) unless stated. Cases and controls were matched for age and smoking status. | ||||
| The p values are for comparison between the case group and control group. The two sample t test was used for continuous variables and χ2 test for categorical variables. The p value for C reactive protein was derived from a logarithmic analysis. The characteristics of the entire WOSCOPS cohort are given for comparison. Formal analysis of these variables to predict coronary heart disease risk has been published elsewhere.19 | ||||
| BP, blood pressure; HDL, high density lipoprotein; LDL, low density lipoprotein. | ||||
| Age (years) | 56.9 (5.1) | 56.7 (5.2) | 0.68 | 55.2 (5.5) |
| Body mass index (kg/m2) | 26.0 (3.1) | 25.6 (3.2) | 0.03 | 26.0 (3.2) |
| Systolic BP (mm Hg) | 139 (17) | 136 (17) | <0.001 | 136 (17) |
| Diastolic BP (mm Hg) | 85 (10) | 84 (10) | 0.002 | 84 (10) |
| Cholesterol (mmol/l) | 7.07 (0.61) | 7.02 (0.58) | 0.10 | 7.03 (0.59) |
| LDL cholesterol (mmol/l) | 5.02 (0.46) | 4.95 (0.44) | 0.005 | 4.97 (0.44) |
| HDL cholesterol (mmol/l) | 1.07 (0.22) | 1.14 (0.25) | <0.001 | 1.14 (0.26) |
| Fibrinogen (g/l) | 4.52 (0.87) | 4.35 (0.86) | <0.001 | − |
| White cell count (×109/l) | 7.06 (1.89) | 6.75 (1.86) | 0.002 | − |
| C reactive protein (mg/l) | 3.88 (4.68) | 3.29 (4.46) | <0.001 | − |
| Smoker (%) | 53.7 | 54.4 | 0.80 | 44.1 |
| Diabetes (%) | 2.1 | 1.2 | 0.17 | 1.2 |
| Hypertension (%) | 23.4 | 15.6 | <0.001 | 15.7 |