Full dose lytic versus half dose lytic plus glycoprotein IIb/IIIa blocker: clinical and angiographic findings
| GUSTO V | ASSENT 3 | TIMI 14 | SPEED | Total* | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| r-PA | r-PA+Abc | TNK | TNK+Abc | rt-PA | rt-PA+Abc | r-PA | r-PA+Abc | ThX | ThX+Abc | |
| n | 8260 | 8328 | 4078 | 2016 | 163 | 173 | 108 | 187 | 12609 | 10704 |
| Mortality % (n) | 5.6 (488) | 5.9 (468) | 5.7 (231) | 6.6 (133) | 3.1 (5) | 4.4 (5) | 5.5 (6) | 3.7 (7) | 5.8 (730) | 5.7 (613) |
| ICH % (n) | −0.6 (49) | 0.6 (52) | 0.9 (37) | 0.9 (19) | 1.8 (3) | 1.2 (2) | 0.9 (1) | 0.5 (1) | 0.7 (90) | 0.7 (74) |
| Major bleeding % (n) | −2.3 (190) | 4.6 (379) | 2.6 (106) | 4.3 (87) | 4.3 (7) | 3.5 (6) | 3.7 (4) | 8.0 (15) | 2.4 (307) | 4.5 (487) |
| Reinfarction | −3.5 (291) | 2.3 (190) | 3.4 (140) | 2.2 (44) | 3.1 (5) | na | 2.8 (3) | 1.6 (3) | 3.5 (439) | 2.3 (237) |
| 90 mins TIMI 3 % | 62 | 74 | 47 | 57 | ||||||
| Intro AMI | Integriti | Total† | Total‡ | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| rt-PA | rt-PA+epti | TNK | TNK+epti | ThX | ThX+epti | ThX | ThX+GP | |||
| *The total of all trials combining abciximab with thrombolysis; †the total of all trials combining eptifibatide with thrombolysis; ‡the total of all trials combining glycoprotein IIb/IIIa blockers with thrombolysis; §TIMI grade 3 percentages at 60 minutes. | ||||||||||
| Abc, abciximab; epti, eptifibatide; GP, glycoprotein receptor blocker; ICH, intracranial haemorrhage; ThX, thrombolysis. | ||||||||||
| n | 100 | 204 | 118 | 177 | 218 | 381 | 12827 | 11085 | ||
| Mortality % (n) | 7.0 (7) | 4.4 (9) | 5.1 (6) | 3.6 (6) | 6.0 (13) | 3.9 (15) | 5.8 (743) | 5.7 (628) | ||
| ICH % (n) | 2.0 (2) | 2.0 (4) | 1.7 (2) | 0.6 (1) | 1.8 (4) | 1.3 (5) | 0.7 (94) | 0.7 (79) | ||
| Major bleeding % (n) | 7.0 (7) | 10.8 (22) | 0.8 (1) | 6.8 (12) | 3.7 (8) | 8.9 (34) | 2.5 (315) | 4.7 (521) | ||
| Reinfarction % (n) | 3.0 (3) | 4.9 (10) | 0 (0) | 4.0 (7) | 1.4 (3) | 4.5 (17) | 3.4 (442) | 2.3 (254) | ||
| 90 mins TIMI 3 % | 54 | 58 | 49§ | 62§ | ||||||