Baseline patient characteristics
| Age <60 years | Age ⩾60 years | p Value | |
|---|---|---|---|
| *Data are mean (SD) (range) or numbers (%). | |||
| CI, cardiac index at maximum workload; FHCM, familial hypertrophic cardiomyopathy; IVS, interventricular septal; LVEDP, left ventricular end diastolic pressure; LVEF, left ventricular ejection fraction; LVOT, left ventricular outflow tract; NYHA, New York Heart Association; PAP, pulmonary artery mean pressure at pretreatment workload; Post-ES, post-extrasystolic gradient; Rest, resting gradient; V̇o2max, oxygen consumption at maximum workload. | |||
| Number of patients | 80 | 77 | |
| Age (years) | 44 (11) (21–59) | 69 (5) (61–83) | <0.001 |
| Male sex | 49 (61%) | 27 (35%) | 0.001 |
| FHCM | 22 (28%) | 15 (19%) | 0.237 |
| Hypertension | 4 (5%) | 7 (9%) | 0.315 |
| NYHA functional class | 2.7 (0.5) | 3.1 (0.4) | <0.001 |
| IV | 2 | 10 | |
| III | 55 | 62 | |
| II | 23 | 5 | |
| Syncope | 23 (29%) | 25 (32%) | 0.613 |
| Pre-implanted DDD pacemaker | 7 (9%) | 7 (9%) | 0.960 |
| IVS thickness (mm) | 23 (4) (16–38) | 22 (3) (15–34) | 0.010 |
| Left heart catheterisation | 80 | 77 | |
| LVOT gradient | |||
| Rest (mm Hg) | 52 (37) (0–140) | 57 (47) (0–158) | 0.815 |
| Post-ES (mm Hg) | 144 (44) (40–236) | 150 (56) (30–250) | 0.413 |
| LVEDP (mm Hg) | 20 (6) (8–38) | 19 (6) (8–35) | 0.292 |
| LVEF | 0.72 (0.07) (0.60–0.87) | 0.73 (0.07) (0.60–0.90) | 0.318 |
| Right heart catheterisation | 75 | 69 | |
| Workload (W) | 91 (30) (0–175) | 57 (28) (0–125) | <0.001 |
| PAP (mm Hg) | 40 (9) (20–59) | 43 (10) (20–69) | 0.025 |
| V̇o2max (ml/kg/min) | 17.4 (4.5) (9.5–28.1) | 12.3 (4.6) (3.9–24.3) | <0.001 |
| V̇o2max (% predicted) | 52 (12) (28–82) | 49 (17) (17–92) | 0.363 |
| CI (l/m2/min) | 6.4 (1.3) (3.5–9.8) | 5.0 (1.7) (1.6–9.7) | <0.001 |