Differences in experimental data between treatment with spironolactone and placebo
| Placebo | Spironolactone | p Value | |
|---|---|---|---|
| Data are mean (SD). *p<0.05; **p<0.01. | |||
| BNP, β-type natriuretic peptide; BSA, body surface area; HAD, hospital anxiety and depression; HR, heart rate; IVSd, interventricular septum thickness; LVIDd, left ventricular end diastolic diameter; LVM, left ventricular mass; LVMI, left ventricular mass index; LVPWd, left ventricular posterior wall thickness; MLWHF, Minnesota living with heart failure; PIIINP, procollagen III N-terminal peptide; PWV, pulse wave velocity; QT, corrected QT interval; QTd, QT dispersion; QTdc, corrected QT dispersion. | |||
| Weight (kg) | 77.2 (10.2) | 76.8 (9.70) | 0.108 |
| SBP (mm Hg) | 135 (21.8) | 126 (24.5) | 0.004** |
| DBP (mm Hg) | 77.4 (9.90) | 72.3 (11.8) | 0.005** |
| HR (beats/min) | 60.0 (12.2) | 58.8 (7.34) | 0.475 |
| Sodium (mmol/l) | 137 (4.20) | 135 (4.30) | 0** |
| Potassium (mmol/l) | 4.36 (0.41) | 4.72 (0.41) | 0** |
| Urea (mmol/l) | 6.15 (1.97) | 7.93 (7.93) | 0** |
| Creatinine (μmol/l) | 91.0 (27.0) | 101 (33.0) | 0** |
| Magnesium (mmol/l) | 0.89 (0.07) | 0.87 (0.07) | 0.044* |
| Urate (mmol/l) | 0.37 (0.08) | 0.37 (0.08) | 0.695 |
| BNP (pg/ml) | 48.5 (29.7) | 36.8 (28.5) | 0.039* |
| PIIINP(μg/l) | 3.767 (1.157) | 3.156 (1.123) | 0** |
| Noradrenaline (pg/ml) | 769 (361) | 851 (383) | 0.114 |
| Adrenaline (pg/ml) | 82.8 (88.9) | 94.7 (74.4) | 0.416 |
| MLWHF score | 16.2 (15.9) | 18.8 (18.6) | 0.044* |
| Physical score | 8.31 (7.97) | 8.86 (8.73) | 0.47 |
| Emotional score | 3.31 (4.55) | 4.02 (5.41) | 0.227 |
| HAD score | 7.05 (6.43) | 8.24 (6.90) | 0.035* |
| Anxiety score | 3.76 (3.71) | 4.24 (3.75) | 0.21 |
| Depression score | 3.31 (3.29) | 4.00 (3.84) | 0.023* |
| 6 minute distance (m) | 472 (81.1) | 466 (13.9) | 0.438 |
| PWV (m/s) | 8.36 (1.27) | 8.23 (1.23) | 0.447 |
| Augmentation | 15.7 (8.91) | 14.3 (7.04) | 0.219 |
| Buckberg | 166 (31.0) | 170 (32.7) | 0.389 |
| QT (ms) | 465 (54.7) | 447 (56.5) | 0.009** |
| QTc (ms) | 473 (43.1) | 455 (35.4) | 0.002** |
| QTd (ms) | 84.5 (41.3) | 72.1 (32.3) | 0.037* |
| QTdc (ms) | 86.0 (39.9) | 73.4 (30.6) | 0.032* |
| BSA (m2) | 1.93 (0.16) | 1.92 (0.16) | 0.393 |
| LVIDd (cm) | 5.40 (0.86) | 5.06 (0.94) | 0.006** |
| IVSd (cm) | 1.15 (0.30) | 1.12 (0.29) | 0.587 |
| LVPWd (cm) | 1.04 (0.26) | 1.11 (0.25) | 0.25 |
| LVM (g) | 235 (81.2) | 215 (71.6) | 0.022* |
| LVMI (g/m2) | 122 (41.0) | 112 (36.3) | 0.036* |