Differences in heart rate variability parameters between treatment with spironolactone and placebo
| Placebo | Spironolactone | p Value | |
|---|---|---|---|
| Data are mean (SD). *p<0.05. | |||
| HF, high frequency; LF, low frequency; RMSSD, root mean square of successive differences between NN intervals; SDANN, standard deviation of the averages of NN intervals; RMSSD, root mean square of successive differences between NN intervals; SDNN, standard deviation of all NN intervals; SDNNI, SDNN index; SVT, supraventricular tachycardia; VLF, very low frequency; VT, ventricular tachycardia. | |||
| Normal QRS | 92 991 (12933) | 93 440 (14 048) | 0.648 |
| SVT | 0.38 (0.85) | 0.51 (1.52) | 0.57 |
| Aberrants | 1 548 (3571) | 1 054 (2845) | 0.211 |
| Extrasystoles | 400 (832) | 300 (711) | 0.03* |
| Couplets | 98.3 (370) | 22.4 (57) | 0.167 |
| Triplets | 12.7 (74.7) | 0.62 (1.76) | 0.317 |
| Salvos | 2.15 (11.7) | 0.18 (0.45) | 0.291 |
| VT | 0.08 (0.27) | 0.10 (0.31) | 0.661 |
| Bradycardia | 53.6 (151) | 47.7 (139) | 0.835 |
| Dropped beat | 3.03 (14.9) | 0.69 (2.66) | 0.251 |
| Pauses | 0.00 (0.00) | 0.00 (0.00) | 0.294 |
| Maximum HR (beats/min) | 100 (15.8) | 98.5 (15.1) | 0.241 |
| Minimum HR (beats/min) | 50.6 (6.29) | 51.3 (6.73) | 0.806 |
| Total QRS | 94 803 (12 564) | 94 538 (13 706) | 0.027* |
| Triangle index | 33.7 (9.61) | 33.0 (9.66) | 0.544 |
| Mean RR (ms) | 932 (131) | 919 (127) | 0.293 |
| SDNN (ms) | 114 (28.7) | 113 (22.7) | 0.803 |
| SDNNI (ms) | 47.9 (13.1) | 44.6 (12.4) | 0.041 |
| SDANN (ms) | 99.2 (26.6) | 100 (21.2) | 0.862 |
| RMSSD (ms) | 28.1 (9.78) | 25.8 (9.52) | 0.039 |
| % analysed | 94.6 (5.57) | 95.7 (4.60) | 0.161 |
| VLF (ms2) | 700 (439) | 697 (387) | 0.974 |
| LF (ms2) | 190 (117) | 166 (98.5) | 0.145 |
| HF (ms2) | 107 (54.6) | 93.1 (60.9) | 0.13 |
| Total power (ms2) | 1 006 (568) | 973 (515) | 0.719 |
| Normalised LF | 57.3 (13.8) | 57.5 (9.10) | 0.97 |
| Normalised HF | 40.2 (10.8) | 38.4 (9.89) | 0.33 |
| LF/HF ratio | 2.05 (0.99) | 2.24 (1.05) | 0.235 |