Variable | Time point | Oestradiol | Placebo | p Value |
---|---|---|---|---|
The values are expressed as mean (SD). | ||||
*p = 0.02 (T1 v T2) in the same group. | ||||
†p = 0.001 (T1 v T3) in the same group. | ||||
D, peak velocity of pulmonary diastolic wave; LA, left atrium; LVM/BSA, left ventricular mass indexed by body surface area; S, peak velocity of pulmonary systolic wave; S/D ratio, the ratio between the peak velocity of pulmonary S and D wave; Vel a, peak velocity of pulmonary a wave. | ||||
S (cm/s) | Baseline (T1) | 64 (16) | 59 (12) | NS |
90 minutes (T2) | 61 (13) | 59 (11) | NS | |
12 weeks (T3) | 61 (10) | 60 (7) | NS | |
D (cm/s) | Baseline (T1) | 41 (10) | 37 (7) | NS |
90 minutes (T2) | 39 (8) | 37 (6) | NS | |
12 weeks (T3) | 40 (8) | 41 (12) | NS | |
S/D ratio | Baseline (T1) | 1.6 (0.3) | 1.6 (0.2) | NS |
90 minutes (T2) | 1.6 (0.3) | 1.6 (0.2) | NS | |
12 weeks (T3) | 1.5 (0.2) | 1.5 (0.2) | NS | |
Vel a (cm/s) | Baseline (T1) | 31 (4) | 30 (3) | NS |
90 minutes (T2) | 29 (3)* | 28 (4)* | NS | |
12 weeks (T3) | 27 (3)† | 29 (2)† | NS | |
LVM/BSA (g/m2) | Baseline (T1) | 113 (29) | 107 (28) | NS |
90 minutes (T2) | 109 (29) | 108 (26) | NS | |
12 weeks (T3) | 103 (20) | 113 (28) | NS | |
LA size (cm) | Baseline (T1) | 3.7 (0.4) | 3.6 (0.4) | NS |
90 minutes (T2) | 3.7 (0.4) | 3.6 (0.4) | NS | |
12 weeks (T3) | 3.7 (0.4) | 3.6 (0.3) | NS |