Predictors of reaching the primary end point* (PEP) in children with DCM
| Variable | PEP reached (n = 30) | PEP not reached (n = 24) | p Value |
|---|---|---|---|
| Data presented as median (25th–75th centile) or as mean (SD) where appropriate. | |||
| *Need for hospitalisation, transplantation, or death as an outcome. | |||
| Demographics | |||
| Age (years) | 5.1 (2.0–13.7) | 3.7 (1.3–8.1) | 0.78 |
| Ventricular dimensions | |||
| LVEDD z score | 3.72 (2.29) | 2.71 (0.30) | 0.13 |
| LVPW z score | −0.33 (−0.63) | 0.55 (1.84) | 0.24 |
| TR and ventricular function | |||
| TR jet velocity (m/s) | 2.8 (0.4) | 2.6 (0.3) | 0.25 |
| LV Tei index | 0.63 (0.20) | 0.48 (0.14) | 0.09 |
| RV Tei index | 0.60 (0.11) | 0.44 (0.11) | <0.001 |
| LVEF (%) | 22 (9–32) | 36 (24–48) | <0.001 |
| RVFAC (%) | 30 (9) | 34 (9) | 0.06 |
| TD measurements | |||
| Mitral lateral Ea (cm/s) | 10.6 (3.8) | 13.5 (4.8) | 0.02 |
| Mitral lateral Aa (cm/s) | 5.4 (2.1) | 5.1 (1.7) | 0.98 |
| Mitral lateral Sa (cm/s) | 6.2 (4.7–8.5) | 7.3 (5.6–8.3) | 0.30 |
| Mitral septal Ea (cm/s) | 6.8 (6.2–8.3) | 10.2 (7.5–12.1) | 0.002 |
| Mitral septal Aa (cm/s) | 4.3 (3.6–6.8) | 6.3 (4.9–7.5) | 0.03 |
| Mitral septal Sa (cm/s) | 4.5 (3.9–5.8) | 6.0 (5.1–7.9) | 0.003 |
| Tricuspid lateral Ea, cm/s | 11.5 (4.7) | 13.8 (3.8) | 0.04 |
| Tricuspid lateral Aa (cm/s) | 8.3 (2.5) | 9.3 (2.6) | 0.17 |
| Tricuspid lateral Sa (cm/s) | 10.2 (7.8–11.7) | 11.5 (9.2–13.5) | 0.15 |