Area under receiver operator characteristic (ROC) curve, sensitivity, specificity, positive and negative predictive values, and likelihood ratios for brain natriuretic peptide and NT-proBNP in the diagnosis of left ventricular systolic dysfunction
| Cohort sampled | Test | AUC (95% CI) | Cut off value (pmol/l) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | LR+ (95% CI) | LR− (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| AUC, area under the curve; CI, confidence interval; HF, heart failure. | |||||||||
| General population over 45 (n = 307) | NT-proBNP | 0.76 (0.46 to 1.0) | 40 | 80% (28 to 100) | 73% (68 to 78) | 5% (1 to 12) | 100% (98 to 100) | 2.95 (1.83 to 4.74) | 0.27 (0.05 to 1.59) |
| BNP | 0.88 (0.75 to 1.0) | 33 | 80% (28 to 100) | 88% (84 to 92) | 10% (3 to 24) | 100% (98 to 100) | 6.71 (3.93 to 11.46) | 0.23 (0.04 to 1.31) | |
| Patients with previous HF diagnosis (n = 103) | NT-proBNP | 0.70 (0.58 to 0.81) | 40 | 100% (87 to 100) | 18% (11 to 28) | 24% (15 to 34) | 100% (82 to 100) | 1.22 (1.10 to 1.36) | 0 (0 to 1.38) |
| BNP | 0.70 (0.59 to 0.82) | 33 | 71% (48 to 89) | 52% (41 to 64) | 28% (17 to 42) | 88% (75 to 95) | 1.50 (1.05 to 2.14) | 0.54 (0.23 to 1.29) | |
| Patients on diuretics (n = 87) | NT-proBNP | 0.81 (0.60 to 1.0) | 40 | 86% (42 to 100) | 40% (29 to 52) | 11% (4 to 23) | 97% (84 to 100) | 1.43 (1.01 to 2.03) | 0.36 (0.06 to 2.24) |
| BNP | 0.80 (0.60 to 0.99) | 33 | 86% (42 to 100) | 65% (54 to 75) | 18% (7 to 35) | 98% (90 to 100) | 2.44 (1.60 to 3.75) | 0.22 (0.04 to 1.36) | |
| Patients at high risk for HF (n = 133) | NT-proBNP | 0.73 (0.62 to 0.84) | 40 | 100% (74 to 100) | 46% (37 to 56) | 13% (7 to 23) | 100% (95 to 100) | 1.86 (1.58 to 2.20) | 0 (0 to 1.01) |
| BNP | 0.70 (0.57 to 0.82) | 33 | 50% (19 to 81) | 67% (58 to 75) | 11% (4 to 24) | 94% (87 to 98) | 1.51 (0.77 to 2.95) | 0.75 (0.33 to 1.70) | |