• High sensitivity excludes disease more accurately and avoids the need for a secondary test if a less accurate primary test is used. |
• High sensitivity leads to fewer false negative tests and avoids the cost of future events in undiagnosed patients with disease |
• High specificity reduces the number of false positive tests and consequent downstream testing |
• Additional prognostic information avoids the need for further prognostic testing and focuses high cost interventional care on patients with advanced disease and with most to gain in terms of clinical outcome |