Case–control analysis: association between antidepressant exposure and first MI
| Drug exposure* | Cases (n = 63512) | Controls (n = 378886) | OR (95% CI) |
|---|---|---|---|
| *At least one prescription before first MI. | |||
| TCA, tricyclic antidepressant; MAOI, monoamine oxidase inhibitor; SSRI, selective serotonin reuptake inhibitor. | |||
| Any antidepressant | 9087 (14.31%) | 40146 (10.6%) | 1.43 (1.40 to 1.47) |
| Any SSRI | 2549 (4.01%) | 10439 (2.76%) | 1.49 (1.43 to 1.56) |
| Any TCA | 7587 (11.95%) | 33726 (8.90%) | 1.41 (1.37 to 1.45) |
| Any MAOI | 87 (0.14%) | 413 (0.11%) | 1.26 (1.00 to 1.59) |
| Any “other” | 491 (0.77%) | 2121 (0.56%) | 1.39 (1.26 to 1.54) |
| Fluoxetine (SSRI) | 1327 (2.09%) | 5225 (1.38%) | 1.54 (1.45 to 1.64) |
| Paroxetine (SSRI) | 870 (1.37%) | 3839 (1.01%) | 1.37 (1.27 to 1.47) |
| Dothiepin (TCA) | 2926 (4.61%) | 13431 (3.54%) | 1.33 (1.27 to 1.38) |
| Amitriptyline (TCA) | 2627 (4.14%) | 11500 (3.04%) | 1.39 (1.33 to 1.46) |
| Lofepramine (TCA) | 1394 (2.19%) | 5647 (1.49%) | 1.49 (1.41 to 1.59) |